Avian Coronavirus NP antibody and antigen (recombinant protein)

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Diagnostic anti-Avian Coronavirus NP antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry, Turkey infectious disease avian infectious bronchitis/gastrointestinal disease in turkey) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P192-Tg001-Ag01	Recombinant Avian Coronavirus NP protein	$3090.00
GMP-VT-P192-Tg001-Ab01	Anti-Avian Coronavirus NP mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P192-Tg001-Ab02	Anti-Avian Coronavirus NP mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P192-Tg001-Ab03	Anti-Avian Coronavirus NP human monoclonal antibody (mAb)	$3090.00
GMP-VT-P192-Tg001-Ab04	Anti-Avian Coronavirus NP human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P192-Tg001-Ag01
Product Name	Recombinant Avian Coronavirus NP protein
Pathogen	Avian Coronavirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Avian Coronavirus NP antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian Coronavirus level test of animal Avian/Bird/Poultry, Turkey infectious disease with avian infectious bronchitis/gastrointestinal disease in turkey.
Tag	His
Product description	Recombinant Avian Coronavirus NP proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P192-Tg001-Ab01,GMP-VT-P192-Tg001-Ab02
Pathogen	Avian Coronavirus
Product Name	Anti-Avian Coronavirus NP mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Avian Coronavirus NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Coronavirus antibodies in Avian Coronavirus level test of animal Avian/Bird/Poultry, Turkey infectious disease with avian infectious bronchitis/gastrointestinal disease in turkey.
Product description	Anti-Avian Coronavirus NP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Coronavirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P192-Tg001-Ab03,GMP-VT-P192-Tg001-Ab04
Pathogen	Avian Coronavirus
Product Name	Anti-Avian Coronavirus NP human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Avian Coronavirus NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Coronavirus antibodies in Avian Coronavirus level test of animal Avian/Bird/Poultry, Turkey infectious disease with avian infectious bronchitis/gastrointestinal disease in turkey.
Product description	Anti-Avian Coronavirus NP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Avian Coronavirus, also known as Infectious Bronchitis Virus (IBV), is a viral disease that primarily affects poultry, including chickens, turkeys, and quails. The illness caused by IBV is highly contagious and results in various respiratory, urinary, and reproductive symptoms. The most notable symptoms of infectious bronchitis are respiratory distress, sneezing, coughing, nasal discharge, and difficulty breathing. Additionally, infected birds may experience kidney damage, decreased egg production, poor eggshell quality, and even death in severe cases.

IBV belongs to the family Coronaviridae, which is a large family of viruses that includes human coronaviruses, such as SARS-CoV-2 that causes COVID-19, as well as other animal coronaviruses. Coronaviruses have a unique structure that includes an outer lipid envelope with club-shaped spike glycoproteins on their surface, which gives them their characteristic crown-like appearance.

The genomic structure of IBV is positive-sense, single-stranded RNA, and approximately 27.6 kilobases in length. The virus's RNA encodes four major structural proteins, including the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins. Each of these proteins plays a crucial role in the viral infection pathway. The S protein facilitates viral attachment and entry into host cells. The E protein is a small structural component important for maintaining the virus's shape. The M protein is the most abundant protein found on the virion surface, providing support to the viral envelope and interacting with other viral proteins. The N protein forms the viral nucleocapsid, which binds to the RNA genome and facilitates its packaging.

There are several diagnostic methods for IBV detection, including Polymerase Chain Reaction (PCR), serological assays, and virus isolation. PCR methods target the S and N genes to detect IBV nucleic acids in infected birds. Serological assays measure antibodies against the S and M proteins produced by the host immune response following viral exposure. Finally, virus isolation involves culturing the virus in cell culture from samples collected from infected birds.

In conclusion, Avian Coronavirus is a significant pathogen that causes infectious bronchitis in poultry. IBV is highly contagious and can cause severe economic losses to the poultry industry worldwide. Advances in diagnostic methods for IBV detection have improved our understanding of the viral infection pathway and increased our capacity to manage and prevent outbreaks. However, continuous surveillance and control measures are necessary to slow down the spread of the disease and protect poultry health and welfare.

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