Salmon isavirus haemagglutinin antibody and antigen (recombinant protein)

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Diagnostic anti-Salmon isavirus haemagglutinin antibodies pairs and antigen for animal health (animal Fish infectious disease Infectious salmon anemia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P228-Tg001-Ag01	Recombinant Salmon isavirus haemagglutinin protein	$3090.00
GMP-VT-P228-Tg001-Ab01	Anti-Salmon isavirus haemagglutinin mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P228-Tg001-Ab02	Anti-Salmon isavirus haemagglutinin mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P228-Tg001-Ab03	Anti-Salmon isavirus haemagglutinin human monoclonal antibody (mAb)	$3090.00
GMP-VT-P228-Tg001-Ab04	Anti-Salmon isavirus haemagglutinin human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P228-Tg001-Ag01
Product Name	Recombinant Salmon isavirus haemagglutinin protein
Pathogen	Salmon isavirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Salmon isavirus haemagglutinin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Salmon isavirus level test of animal Fish infectious disease with Infectious salmon anemia.
Tag	His
Product description	Recombinant Salmon isavirus haemagglutinin proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P228-Tg001-Ab01,GMP-VT-P228-Tg001-Ab02
Pathogen	Salmon isavirus
Product Name	Anti-Salmon isavirus haemagglutinin mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Salmon isavirus haemagglutinin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmon isavirus antibodies in Salmon isavirus level test of animal Fish infectious disease with Infectious salmon anemia.
Product description	Anti-Salmon isavirus haemagglutinin mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmon isavirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P228-Tg001-Ab03,GMP-VT-P228-Tg001-Ab04
Pathogen	Salmon isavirus
Product Name	Anti-Salmon isavirus haemagglutinin human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Salmon isavirus haemagglutinin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmon isavirus antibodies in Salmon isavirus level test of animal Fish infectious disease with Infectious salmon anemia.
Product description	Anti-Salmon isavirus haemagglutinin mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Introduction:

Salmon isavirus (SAV) is a single-stranded RNA virus that belongs to the family Orthomyxoviridae, which also includes the influenza virus. SAV primarily infects Atlantic salmon, a species of fish that is economically important in many regions around the world. Here, we will explore the structure and classification of SAV, its impact on Atlantic salmon populations, and current diagnostic methods for identifying SAV infections.

Structure and Classification:

SAV is a negative-sense RNA virus, meaning that its genetic material must be transcribed into a complementary positive-sense RNA strand before it can be translated into viral proteins. The SAV genome is approximately 11 kilobases in length and encodes for several proteins, including the RNA-dependent RNA polymerase, nucleoprotein, and matrix protein. These proteins are essential for virus assembly, replication, and virulence.

SAV is classified as an alphavirus, a group of positive-sense RNA viruses that includes several important human and animal pathogens. Alphaviruses are known for their ability to cause severe diseases in their hosts, making them a significant public health concern.

Impact on Atlantic Salmon Populations:

SAV primarily infects Atlantic salmon, a species of fish that is an important source of food and income for many communities. SAV infections can cause a range of diseases collectively known as salmonid alphavirus (SAV) infection, which includes pancreatic disease (PD) and sleeping disease (SD).

PD is characterized by damage to the pancreas, liver, and other organs, leading to significant weight loss and increased mortality rates in infected fish. In contrast, SD causes lethargy and abnormal swimming behavior in infected fish, which can make them more vulnerable to predation and less likely to successfully migrate upstream to spawn.

SAV infections can have serious consequences for both wild and farmed Atlantic salmon populations. In some regions, SAV outbreaks have led to significant declines in salmon productivity and economic losses for local communities. As such, there is a need for effective diagnostic methods to detect SAV infections and prevent the spread of the virus.

Diagnostic Methods:

Diagnosing SAV infections can be challenging, as the disease can present with a wide range of symptoms and may be difficult to distinguish from other fish diseases. However, several diagnostic methods are currently available for identifying SAV infections.

Serological tests, which detect antibodies produced by fish in response to the virus, are commonly used to screen for SAV infections. These tests can help identify whether a fish has been exposed to SAV and can be useful for monitoring disease prevalence in wild and farmed populations.

Molecular tests targeting specific viral genes, such as the RNA polymerase or nucleoprotein gene, are also used to diagnose SAV infections. These tests include reverse transcription polymerase chain reaction (RT-PCR) and loop-mediated isothermal amplification (LAMP). These molecular tests are highly sensitive and specific, making them valuable tools for detecting SAV infections in fish populations.

Conclusion:

In conclusion, Salmon isavirus (SAV) is a single-stranded RNA virus that primarily infects Atlantic salmon populations, causing a range of diseases collectively known as salmonid alphavirus (SAV) infection. SAV infections can have serious consequences for both wild and farmed salmon populations, making effective diagnostic methods essential for disease prevention and management. While several diagnostic methods are currently available for identifying SAV infections, ongoing research is needed to develop new tools for controlling and eradicating this important fish pathogen.

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