Staphylococcus saprophyticus antibody and antigen (recombinant protein)

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Diagnostic anti-Staphylococcus saprophyticus antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease urinary tract infections) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P233-Ag01	Recombinant Staphylococcus saprophyticus protein	$3090.00
GMP-VT-P233-Ab01	Anti-Staphylococcus saprophyticus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P233-Ab02	Anti-Staphylococcus saprophyticus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P233-Ag01
Product Name	Recombinant Staphylococcus saprophyticus protein
Pathogen	Staphylococcus saprophyticus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Staphylococcus saprophyticus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Staphylococcus saprophyticus level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with urinary tract infections.
Tag	His
Product description	Recombinant Staphylococcus saprophyticus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P233-Ab01,GMP-VT-P233-Ab02
Pathogen	Staphylococcus saprophyticus
Product Name	Anti-Staphylococcus saprophyticus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Staphylococcus saprophyticus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Staphylococcus saprophyticus antibodies in Staphylococcus saprophyticus level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with urinary tract infections.
Product description	Anti-Staphylococcus saprophyticus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Staphylococcus saprophyticus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Staphylococcus saprophyticus is a Gram-positive coccus bacterium that belongs to the phylum Firmicutes, class Bacilli, and order Bacillales. It is a facultative anaerobe that grows in clusters and produces catalase enzyme, which enables it to detoxify hydrogen peroxide produced by immune cells. This makes it an important pathogen in human infections.

The pathogen's structure is composed of various genes and proteins that contribute to its virulence and survival. The extracellular adherence protein (Eap) plays a significant role in the pathogenesis of urinary tract infections (UTIs) caused by Staphylococcus saprophyticus. It has been found that Eap mediates biofilm formation and adhesion to host cells by binding to fibronectin and promoting colonization. Moreover, Eap also induces inflammatory responses in host cells, leading to tissue damage.

In addition to Eap, other important proteins include the clumping factor B (ClfB), fibronectin-binding protein A (FnBPA), and the Sdr protein family. ClfB and FnBPA mediate attachment of the pathogen to host cells and extracellular matrix components, while the Sdr protein family binds to fibrinogen, fibronectin, and collagen.

Staphylococcus saprophyticus primarily infects humans, specifically young sexually active women, and is a leading cause of community-acquired UTIs. The bacterium colonizes in the urogenital tract and can ascend through the urethra to the bladder, causing infections such as cystitis. Unlike other Staphylococcus species, Staphylococcus saprophyticus does not colonize in the skin or nasal passages.

Besides UTIs, Staphylococcus saprophyticus can also cause other infections such as wound infections, bloodstream infections, and endocarditis. In wound infections, Staphylococcus saprophyticus produces enzymes such as lipase and protease to break down host tissues and evade the immune system. This results in the formation of abscesses, which can progress to sepsis if left untreated. In bloodstream infections, Staphylococcus saprophyticus can cause septic shock and multiple organ failure.

Diagnostic methods for Staphylococcus saprophyticus include culture-based assays such as urine or blood culture. However, because Staphylococcus saprophyticus is a slow-growing bacterium, the sensitivity of culture-based assays is low. As a result, molecular techniques such as PCR-based assays targeting genes such as 16S rRNA, nuclease (nuc), and mecA are more commonly used for diagnosis. Additional biochemical tests such as the coagulase and catalase test can be used for species identification.

In conclusion, Staphylococcus saprophyticus is a Gram-positive coccus bacterium that primarily infects humans, causing UTIs and other infections such as wound infections, bloodstream infections, and endocarditis. Its structure includes various genes and proteins that contribute to its virulence and survival, and diagnostic methods include culture-based assays and molecular techniques such as PCR-based assays targeting genes such as 16S rRNA, nuc, and mecA.

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