Trichophyton mentagrophytes antibody and antigen (recombinant protein)

Diagnostic anti-Trichophyton mentagrophytes antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Swine/Porcine/Pig infectious disease dermatophytosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P236-Ag01 Recombinant Trichophyton mentagrophytes protein $3090.00
GMP-VT-P236-Ab01 Anti-Trichophyton mentagrophytes mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P236-Ab02 Anti-Trichophyton mentagrophytes mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P236-Ag01
Product Name Recombinant Trichophyton mentagrophytes protein
Pathogen Trichophyton mentagrophytes
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Trichophyton mentagrophytes antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Trichophyton mentagrophytes level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Swine/Porcine/Pig infectious disease with dermatophytosis.
Tag His
Product description Recombinant Trichophyton mentagrophytes proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P236-Ab01,GMP-VT-P236-Ab02
Pathogen Trichophyton mentagrophytes
Product Name Anti-Trichophyton mentagrophytes mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Trichophyton mentagrophytes antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Trichophyton mentagrophytes antibodies in Trichophyton mentagrophytes level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Swine/Porcine/Pig infectious disease with dermatophytosis.
Product description Anti-Trichophyton mentagrophytes mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Trichophyton mentagrophytes antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen


    Trichophyton mentagrophytes: Understanding the Dermatophyte Pathogen

    Introduction to Trichophyton mentagrophytes:

    Trichophyton mentagrophytes, colloquially known as T. mentagrophytes, stands as a prominent member within the dermatophyte family, a class of keratinophilic fungi notorious for their pathogenicity in keratin-rich tissues. These fungi find their niche in infecting both human and animal hosts, causing dermatophytosis, commonly recognized as ringworm infections. Understanding the intricate details of this pathogen is crucial for precise diagnosis and effective management of associated infections.

    Taxonomy and Classification:

    Within the fungal kingdom, T. mentagrophytes is classified as a eukaryotic organism. Its inclination toward keratinized substrates defines its dermatophytic nature, differentiating it from other fungal entities. The pathogen's ability to invade and degrade keratin is primarily facilitated by the production of keratinase enzymes, essential for its survival and virulence.

    Structural Attributes and Virulence Mechanisms:

    T. mentagrophytes owes its pathogenic potential to the robust enzymatic machinery it possesses. Keratinase enzymes serve as the primary arsenal, enabling the breakdown of keratin, the structural protein abundant in skin, hair, and nails. This ability to metabolize keratin as a nutrient source positions T. mentagrophytes as a formidable invader of keratin-rich tissues.

    The genetic underpinnings of T. mentagrophytes include genes responsible for keratinase production, influencing its pathogenicity and survival. Additionally, a spectrum of proteases complements the pathogen’s virulence strategy by aiding in tissue invasion and nutrient acquisition.

    Hosts Infected and Disease Manifestations:

    Trichophyton mentagrophytes exhibits a broad host range, affecting humans and various animal species. In human hosts, T. mentagrophytes infections result in dermatophytosis, presenting as different clinical entities such as tinea corporis (ringworm of the body), tinea capitis (ringworm of the scalp), tinea pedis (athlete's foot), and other localized skin infections. The manifestations in animals, including domestic pets like dogs and cats, rodents, and other mammals, often result in contagious ringworm infections. Notably, these animal infections bear zoonotic potential, posing a risk of transmission to humans.

    Diagnostic Approaches:

    Accurate identification of T. mentagrophytes infections demands a multi-pronged diagnostic strategy. Conventional methodologies involve microscopic examination of skin scrapings or hair samples, followed by culturing on specialized media for pathogen isolation and identification.

    In recent years, molecular diagnostic methods have gained traction, particularly nucleic acid-based techniques. These advanced methods focus on specific genetic markers:

    The Internal Transcribed Spacer (ITS) region within the fungal ribosomal RNA genes.

    The β-tubulin gene, renowned for its species-specific identification.

    Genetic targets encompassing keratinase and protease genes, detectable through techniques like Polymerase Chain Reaction (PCR).

    Conclusion:

    Trichophyton mentagrophytes, a formidable dermatophyte, stands as a significant causative agent of dermatophytosis in humans and animals. Understanding its genetic, structural, and pathogenic aspects is imperative for effective diagnosis, management, and control of associated infections.

    This comprehensive understanding of T. mentagrophytes serves as a foundational pillar in the field of mycology, guiding effective treatment regimens and preventive measures against dermatophyte-induced ailments in both human and veterinary medicine.



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