Microsporum gypseum antibody and antigen (recombinant protein)

Diagnostic anti-Microsporum gypseum antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine infectious disease tinea or ringworm) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P251-Ag01 Recombinant Microsporum gypseum protein $3090.00
GMP-VT-P251-Ab01 Anti-Microsporum gypseum mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P251-Ab02 Anti-Microsporum gypseum mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P251-Ag01
Product Name Recombinant Microsporum gypseum protein
Pathogen Microsporum gypseum
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Microsporum gypseum antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Microsporum gypseum level test of animal Cat/Feline, Dog/Canine infectious disease with tinea or ringworm.
Tag His
Product description Recombinant Microsporum gypseum proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P251-Ab01,GMP-VT-P251-Ab02
Pathogen Microsporum gypseum
Product Name Anti-Microsporum gypseum mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Microsporum gypseum antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Microsporum gypseum antibodies in Microsporum gypseum level test of animal Cat/Feline, Dog/Canine infectious disease with tinea or ringworm.
Product description Anti-Microsporum gypseum mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Microsporum gypseum antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen


    Microsporum gypseum is a fungal pathogen that infects the skin, hair, and nails of various animals and humans. The fungus belongs to the Arthrodermataceae family of eukaryotic dermatophytes, which are characterized by their ability to invade keratinized tissues. In this article, we will delve into the classification, genetics, host range, diseases caused by, and diagnosis of Microsporum gypseum.

    Classification:

    Microsporum gypseum is a filamentous fungus belonging to the phylum Ascomycota and the class Eurotiomycetes. It is further classified in the order Onygenales and the family Arthrodermataceae. Unlike other fungi, which usually have unicellular or multicellular structures, dermatophytes like Microsporum gypseum have specialized structures such as keratinases and proteases, which allow them to break down keratin— a protein found in the skin, hair, and nails.

    Genetics:

    The genome of Microsporum gypseum has not yet been fully sequenced, making it difficult to elucidate the genetic basis of its pathogenicity. However, studies have identified putative genes and proteins that may be involved in key processes such as cell division and cell wall synthesis. For example, the chitin synthase 1 gene, which codes for chitin synthesis, is known to play a role in fungal cell wall biogenesis. Additionally, beta-tubulin, a microtubule protein that is essential for proper cell division, is also present in Microsporum gypseum.

    Host Range and Diseases:

    Microsporum gypseum can infect a variety of hosts, including humans, dogs, cats, horses, and rodents. In humans, infections usually present as tinea corporis (ringworm), tinea capitis (scalp ringworm), and tinea pedis (athlete's foot). Tinea corporis is a fungal infection that appears as a scaly, raised rash on the body's most exposed regions, such as the arms, legs, or face. Tinea capitis, on the other hand, presents as patches of hair loss on the scalp, which may or may not be accompanied by scaling or redness. Finally, tinea pedis, or athlete's foot, is an infection that affects the feet, with symptoms such as itching, scaling, and redness.

    In animals, Microsporum gypseum infections are collectively referred to as dermatophytosis or "ringworm" due to the characteristic circular shape of the lesions. In horses, the fungus typically causes scaling and crusty lesions in the mane and tail, while in dogs and cats, the infection usually manifests as circular patches of hair loss on the face, ears, limbs, or trunk. In rodents, Microsporum gypseum infections can cause severe skin ulcers and scabs.

    Diagnosis:

    Diagnosing Microsporum gypseum infections requires a combination of approaches, including clinical examination, direct microscopy, fungal culture, and molecular assays such as PCR. In some cases, skin scrapings or hair samples may be collected for testing. The Gold Standard for diagnosing Microsporum gypseum infections is fungal culture, which involves growing the pathogen on an agar medium and observing its characteristic morphology under the microscope. Direct microscopy can also be used to visualize the fungal structures in the skin or hair samples, but the sensitivity and specificity are relatively low. PCR-based assays have emerged as a more sensitive and specific method for detecting Microsporum gypseum DNA. Specifically, the ITS region of the fungal rRNA gene, beta-tubulin, and chitin synthase 1 gene are commonly targeted in these assays.

    In conclusion, Microsporum gypseum is a dermatophytic fungus that causes infections in a wide range of hosts, including humans, dogs, cats, horses, and rodents. It is classified as a filamentous ascomycete and possesses several putative genes and proteins involved in important cellular processes. Diagnosis usually involves a combination of clinical examination and laboratory testing, with fungal culture and PCR-based assays standing out as the most reliable methods for detecting the pathogen.



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