Citrobacter freudii antibody and antigen (recombinant protein)

Diagnostic anti-Citrobacter freudii antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Equine/Horse, Fish, Swine/Porcine/Pig infectious disease gastroenteritis, neonatal meningitis, and septicemia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P255-Ag01 Recombinant Citrobacter freudii protein $3090.00
GMP-VT-P255-Ab01 Anti-Citrobacter freudii mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P255-Ab02 Anti-Citrobacter freudii mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P255-Ag01
Product Name Recombinant Citrobacter freudii protein
Pathogen Citrobacter freudii
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Citrobacter freudii antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Citrobacter freudii level test of animal Cat/Feline, Dog/Canine, Equine/Horse, Fish, Swine/Porcine/Pig infectious disease with gastroenteritis, neonatal meningitis, and septicemia.
Tag His
Product description Recombinant Citrobacter freudii proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P255-Ab01,GMP-VT-P255-Ab02
Pathogen Citrobacter freudii
Product Name Anti-Citrobacter freudii mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Citrobacter freudii antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Citrobacter freudii antibodies in Citrobacter freudii level test of animal Cat/Feline, Dog/Canine, Equine/Horse, Fish, Swine/Porcine/Pig infectious disease with gastroenteritis, neonatal meningitis, and septicemia.
Product description Anti-Citrobacter freudii mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Citrobacter freudii antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen


    Aspergillus brasiliensis: A Comprehensive Overview

    Pathogen Name and Description:

    Aspergillus brasiliensis, scientifically known as A. brasiliensis, represents a distinctive variant of the filamentous fungus Aspergillus niger. This pathogen is characterized by a combination of unique morphological and genetic traits that set it apart within the Aspergillus species.

    Pathogen Classification:

    Aspergillus brasiliensis falls within the kingdom Fungi and is classified under the phylum Ascomycota. Specifically, it belongs to the class Eurotiomycetes, a group of fungi known for their morphological diversity and ecological significance. The genus Aspergillus, to which A. brasiliensis belongs, is renowned for its characteristic filamentous growth and the formation of conidial heads, which serve as the means for asexual reproduction.

    Pathogen Structure:

    Understanding the structural components of Aspergillus brasiliensis is vital for comprehending its biology and potential impact. Key genetic and protein elements in its structure include:

    Beta-Glucan Synthase Genes and Proteins: One of the critical constituents of the fungal cell wall is beta-glucan. Genes and proteins involved in beta-glucan synthesis are pivotal for the pathogen's structural integrity and resistance to environmental challenges.

    Cytochrome P450 Enzymes: Aspergillus brasiliensis, like other fungi, possesses cytochrome P450 enzymes. These multifunctional enzymes play a crucial role in drug metabolism and the biosynthesis of secondary metabolites, contributing to the fungus's adaptability and defense mechanisms.

    Species-Specific Genes: Within the genome of Aspergillus brasiliensis, there are likely genes that are unique to this variant. These species-specific genes could encode for traits that distinguish A. brasiliensis from other Aspergillus species, potentially affecting its pathogenicity and ecological niche.

    Hosts and Associated Diseases:

    Aspergillus brasiliensis is a versatile pathogen, capable of infecting various hosts, including humans and plants. In humans, its presence is linked to several diseases, including:

    Invasive Aspergillosis: This severe and often fatal fungal infection primarily targets individuals with compromised immune systems. It can lead to pneumonia and invasive mycosis, posing a significant clinical challenge.

    Allergic Bronchopulmonary Aspergillosis (ABPA): A distinct clinical entity, ABPA represents an allergic response to the presence of Aspergillus species in the respiratory system. It is typically observed in patients with underlying respiratory conditions, such as asthma and cystic fibrosis.

    Respiratory Tract Colonization: In some instances, Aspergillus brasiliensis can colonize the respiratory tract and sinuses without causing overt clinical disease. Such colonization can contribute to a range of respiratory symptoms and may require clinical monitoring.

    Beyond human infections, Aspergillus brasiliensis is known to affect plants, contributing to spoilage of agricultural products and contamination of food and feed. Understanding its impact on both human health and agriculture is crucial for devising effective control and management strategies.

    Diagnostic Methods:

    Accurate diagnosis of Aspergillus brasiliensis infections is fundamental for timely treatment and effective management. A variety of diagnostic methods are employed, encompassing both traditional and molecular techniques, including those targeting nucleic acids. Notable diagnostic methods and their corresponding genes or proteins include:

    Polymerase Chain Reaction (PCR): PCR technology allows for the amplification of specific genomic regions, often focusing on conserved regions like the internal transcribed spacer (ITS) region. This molecular technique is invaluable for precise identification of the pathogen.

    DNA Sequencing: DNA sequencing techniques are employed to determine the genetic makeup of the fungus, specifically by sequencing conserved regions. Such analysis can confirm the identity of Aspergillus brasiliensis and provide insights into genetic variations within this variant.

    Antigen Detection: Immunoassays designed to detect Aspergillus-specific antigens, such as galactomannan and beta-D-glucan, present in the fungal cell wall. The quantitative measurement of these antigens is a valuable tool for early diagnosis and monitoring of fungal infections.

    Immunohistochemistry: This diagnostic approach involves the use of specific antibodies to detect fungal proteins within tissue samples. It plays a crucial role in histopathological diagnosis, aiding in the identification of Aspergillus brasiliensis in clinical settings.

    These diagnostic methods, whether based on nucleic acid analysis or antigen detection, represent critical tools for healthcare professionals and researchers dealing with Aspergillus brasiliensis infections. They facilitate early and accurate diagnosis, which is essential for effective patient management and control of fungal diseases in various contexts, including clinical, agricultural, and research settings.

    In conclusion, Aspergillus brasiliensis, as a variant of Aspergillus niger, is a fascinating fungal pathogen with a notable impact on both human health and agriculture. Its distinct genetic features, diverse hosts, and diagnostic challenges make it a subject of ongoing scientific research and clinical interest. A comprehensive understanding of this pathogen's biology and its diagnostic methods is essential for addressing the associated diseases and ensuring food safety and agricultural product preservation.



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