Cryptosporidium parvum antibody and antigen (recombinant protein)

Diagnostic anti-Cryptosporidium parvum antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease Cryptosporidiosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P259-Ag01 Recombinant Cryptosporidium parvum protein $3090.00
GMP-VT-P259-Ab01 Anti-Cryptosporidium parvum mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P259-Ab02 Anti-Cryptosporidium parvum mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P259-Ag01
Product Name Recombinant Cryptosporidium parvum protein
Pathogen Cryptosporidium parvum
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Cryptosporidium parvum antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Cryptosporidium parvum level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with Cryptosporidiosis.
Tag His
Product description Recombinant Cryptosporidium parvum proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P259-Ab01,GMP-VT-P259-Ab02
Pathogen Cryptosporidium parvum
Product Name Anti-Cryptosporidium parvum mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Cryptosporidium parvum antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Cryptosporidium parvum antibodies in Cryptosporidium parvum level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with Cryptosporidiosis.
Product description Anti-Cryptosporidium parvum mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Cryptosporidium parvum antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Pathogen


    Cryptosporidium parvum is a highly infectious pathogen of significant importance worldwide. It is a unicellular parasite that belongs to the phylum Apicomplexa, which also includes other medically important parasites such as Plasmodium and Toxoplasma. Cryptosporidium parvum is responsible for causing cryptosporidiosis, an intestinal disease characterized by diarrhea, vomiting, dehydration, and stomach cramps. The illness can be severe, particularly in children and people with weakened immune systems, and may lead to death if left untreated.

    The complex structure of Cryptosporidium parvum includes various important genes and proteins that play essential roles in its biological functions. Among these, the Cryptosporidium oocyst wall protein (COWP) is considered critical, since it plays an essential role in the formation of the oocyst, the infectious form of the parasite. The COWP gene has been widely employed in molecular detection assays, and has proven useful as a target for vaccines and therapeutic agents. Other notable proteins produced by Cryptosporidium parvum include the Cryptosporidium sporozoite surface protein 2 (SSP2), which is involved in the parasite's invasion and uptake into host cells, and the Cryptosporidium parvum antigen 18 (CPA18), which is known to be highly immunogenic and may contribute to the host's immune response against the pathogen.

    Cryptosporidium parvum infects a wide range of hosts including humans, cattle, sheep, horses, pigs, dogs, cats, rodents, and many other domestic and wild animals. It is transmitted through the fecal-oral route, via contaminated food or water, or through direct contact with infected individuals or animals. The pathogen can also be present in aerosols produced by contaminated water sources, leading to airborne transmission of the disease.

    Given the significant public health impact of Cryptosporidium parvum, there is a growing need for rapid and reliable diagnostic methods to detect and confirm infections. Microscopy, which relies on visual examination of stool samples, has been one of the traditional methods used to identify the parasite, but it has limitations in terms of sensitivity and specificity, particularly when applied to samples with low levels of parasite load. Immunoassays that use antibodies against Cryptosporidium antigens have become more commonly employed, with several commercial enzyme-linked immunosorbent assays (ELISAs) available. However, molecular techniques such as polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP) have proven to be highly sensitive and specific, and are increasingly being used for diagnosis. PCR methods can target various genes, including the 18S rRNA gene, the COWP gene, and the heat shock protein 70 (HSP70) gene, among others. Proteomic techniques have also been developed to detect Cryptosporidium-specific antigens, such as the Cp23 protein targeted by the ELISA.

    In conclusion, Cryptosporidium parvum is a major pathogen responsible for causing cryptosporidiosis and other diseases in humans and animals worldwide. Its complex structure and genetic makeup require sophisticated and reliable diagnostic methods to detect and manage infections effectively. The development of new therapeutic agents and vaccines targeting important genes and proteins of the pathogen is also underway, highlighting the importance of continued research into this important infectious agent.



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