Heparin-binding protein (HBP) antibody and antigen (Recombinant protein)

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Diagnostic Heparin-binding protein (HBP) antibodies (anti-Heparin-binding protein, anti-HBP) and antigens (recombinant Heparin-binding protein (HBP) protein) for Inflammation/autoimmune/inflammatory disease HBP detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-HBP-Ag01	Recombinant human ALB Protein	$3090.00
GMP-h-HBP-Ab01	Anti-human HBP mouse monoclonal antibody (mAb)	$1953.00
GMP-h-HBP-Ab02	Anti-human HBP mouse monoclonal antibody (mAb)	$1953.00
GMP-h-HBP-Ab03	Anti-human HBP human monoclonal antibody (mAb)	$1953.00
GMP-h-HBP-Ab04	Anti-human HBP human monoclonal antibody (mAb)	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Pruducts	GMP-h-HBP-Ag01
Product Name	Recombinant human ALB Protein
Target/Biomarker	Heparin-binding protein (HBP)
Alias of Target/Biomarker	#N/A
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Heparin-binding protein (ALB) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ALB level test of Inflammation/autoimmune/inflammatory disease (inflammation/autoimmune/ inflammatory disease) and related syndrome evaluation
Products description	Recombinant Human Heparin-binding protein (HBP) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-HBP-Ab01,GMP-h-HBP-Ab02
Product Name	Anti-human HBP mouse monoclonal antibody (mAb)
Target/Biomarker	Heparin-binding protein (HBP)
Alias of Target/Biomarker	#N/A
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human Heparin-binding protein (HBP) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Heparin-binding protein (HBP) antibodies in HBP level test of Inflammation/autoimmune/inflammatory disease (inflammation/autoimmune/ inflammatory disease) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human HBP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other Heparin-binding protein (HBP) antibodies.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-HBP-Ab03,GMP-h-HBP-Ab04
Product Name	Anti-human HBP human monoclonal antibody (mAb)
Target/Biomarker	Heparin-binding protein (HBP)
Alias of Target/Biomarker	#N/A
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human Heparin-binding protein (HBP) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Heparin-binding protein (HBP) antibodies in HBP level test of Inflammation/autoimmune/inflammatory disease (inflammation/autoimmune/ inflammatory disease) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human HBP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

The incidence of sepsis increases with ageing, rise in cancer incidence and popularity of invasive medical operations.1 2 Rapid detection and optimised treatment are the keys to successful treatment of sepsis.3 To facilitate earlier recognition and more timely management of patients with sepsis or those at risk of developing the condition, the European Society of Intensive Care Medicine and Society of Critical Care Medicine published new diagnostic criteria for sepsis and septic shock.4 Nevertheless, due to time delay, low sensitivity and lack of specificity,5 the existing diagnosis indicators such as microbial culture, complete blood count, and levels of procalcitonin (PCT) and C reactive protein (CRP) are inadequate for timely clinical diagnosis of sepsis and septic shock. Heparin-binding protein (HBP) is precomposed and mainly exists in the azurophilic granules (almost 74% in content) and secretory vesicles (almost 18% in content) of neutrophils. Azurophilic granules show low tendency to be released from cells, and they are only released when neutrophils infiltrate tissues.6 The release of easily mobilised HBP from secretory vesicles has important functions during early events in inflammatory processes. HBP works by activating various cell types.7 Previous studies have shown that the plasma HBP level is significantly elevated in sepsis combined with organ dysfunction, which is the best probe for the progression of sepsis.3 8 Given the capacity of HBP to identify infection and vascular leakage in patients, it is also an interesting candidate marker to monitor patients with sepsis and septic shock.

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