Products
Trebananib Biosimilar Fusion Protein (ANGPT2) for Research
Pre-Made Trebananib Biosimilar, Fusion Protein targeting ANGPT2 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AGPT2/ANG2/LMPHM10 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Trebananib is an anti-angiopoietin peptibody comprising a peptide with angiopoietin-binding properties that is fused to the Fc (crystallizable fragment) region of an antibody and inhibits the interaction between the ligands angiopoietin-1 and angiopoietin-2 with the Tie-2 receptor. Trebananib inhibit angiogenesis and may eventually lead to an inhibition of tumor cell proliferation.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-INN-1034-1mg | 1mg | 3090 |
| GMP-Bios-INN-1034-10mg | 10mg | |
| GMP-Bios-INN-1034-100mg | 100mg | |
| GMP-Bios-INN-1034-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Trebananib Biosimilar, Fusion Protein targeting ANGPT2 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AGPT2/ANG2/LMPHM10 |
| INN Name | Trebananib |
| Target | ANGPT2 |
| Format | Fusion Protein |
| Derivation | human |
| Species Reactivity | human |
| CH1 Isotype | Fusion - IGHG1 Fc (Fragment constant) - [peptide 14-mer - peptide 14-mer]2 |
| VD LC | Fusion - IGHG1 Fc (Fragment constant) - [peptide 14-mer - peptide 14-mer]2 |
| Highest_Clin_Trial (Jan '20) | |
| Est. Status | |
| 100% SI Structure | |
| 99% SI Structure | |
| 95-98% SI Structure | |
| Year Proposed | |
| Year Recommended | |
| Companies | Amgen (Thousand Oaks CA USA) |
| Conditions Approved | |
| Conditions Active | |
| Conditions Discontinued | |
| Development Tech | Peptide phage display library |
About target - ANGPT2
1. Protein Angiopoietin-2
2. Gene ANGPT2
3. Organism Homo sapiens (Human)
Function
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
