Pre-Made Acazicolcept Biosimilar, Fusion Protein targeting CD28 fused with human IGHG1 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting Tp44 for drug discovery and mechanism of action (MOA) research

Pre-Made Acazicolcept Biosimilar, Fusion Protein targeting CD28 fused with human IGHG1 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting Tp44 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by generalized fibrosis affecting particularly the lungs and skin. CD28 and ICOS are critical costimulatory receptors that together regulate the activation, differentiation and proliferation of a range of T cells that may play a role in autoimmune and inflammatory disease. Acazicolcept is a single protein domain, or vIgD (Variant Ig Domain) based on a human inducible T cell costimulator ligand (ICOSL) that is capable of binding to both CD28 and ICOS. By simultaneously blocking these two key costimulatory pathways, acazicolcept has the potential to improve clinical outcomes in patients suffering from severe autoimmune and inflammatory disease

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Catalog No.	Package	Price(In USD)	Qty (Quantity)	Sum(In USD)
GMP-Bios-INN-715-1mg	1mg	3090
GMP-Bios-INN-715-10mg	10mg	Inquiry
GMP-Bios-INN-715-100mg	100mg	Inquiry
GMP-Bios-INN-715-xmg	≥100mg	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Products Name (INN Index)	Pre-Made Acazicolcept Biosimilar, Fusion Protein targeting CD28 fused with human IGHG1 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting Tp44
INN Name	Acazicolcept
Target	CD28
Format	Fusion Protein
Derivation	human
Species Reactivity	human
CH1 Isotype	Fusion - [ICOSLG (inducible T-cell co- stimulator ligand, B7H2, B7-H2, ICOS-L, B7-related protein 1, B7RP1, B7RP-1, B7 homolog 2, B7 homologue 2, GL50, KIAA0653, CD275) N-terminal fragment (1-122)]2 - IGHG1 Fc (Fragment constant)
VD LC	Fusion - [ICOSLG (inducible T-cell co- stimulator ligand, B7H2, B7-H2, ICOS-L, B7-related protein 1, B7RP1, B7RP-1, B7 homolog 2, B7 homologue 2, GL50, KIAA0653, CD275) N-terminal fragment (1-122)]2 - IGHG1 Fc (Fragment constant)
Highest_Clin_Trial (Jan '20)
Est. Status
100% SI Structure
99% SI Structure
95-98% SI Structure
Year Proposed
Year Recommended
Companies	Alpine Immune Sciences (Seattle WA USA)
Conditions Approved
Conditions Active
Conditions Discontinued
Development Tech	0