human, Cynomolgus/ Rhesus macaque, rat, mouse erb-b2 receptor tyrosine kinase 2(ERBB2) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse erb-b2 receptor tyrosine kinase 2 (ERBB2) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T14597-Ag-1erb-b2 receptor tyrosine kinase 2 (ERBB2) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T14597-Ab-1Anti-ERBB2 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T14597-Ab-2Anti-ERBB2 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T14597-Ag-1erb-b2 receptor tyrosine kinase 2 (ERBB2)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T14597-Ab-1Anti-ERBB2 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T14597-Ab-2Anti-ERBB2 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T14597-Ag-1erb-b2 receptor tyrosine kinase 2 (ERBB2)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T14597-Ab-1Anti-ERBB2 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T14597-Ab-2Anti-ERBB2 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T14597-Ag-1erb-b2 receptor tyrosine kinase 2 (ERBB2)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T14597-Ab-1Anti-ERBB2 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T14597-Ab-2Anti-ERBB2 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameERBB2
Full nameerb-b2 receptor tyrosine kinase 2
Gene ID2064
Gene NameERBB2
Gene AliasCD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T14597-Ag-1, GM-Tg-rg-T14597-Ag-1, GM-Tg-mg-T14597-Ag-1, GM-Tg-cynog-T14597-Ag-1
Products Nameerb-b2 receptor tyrosine kinase 2 (ERBB2) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse erb-b2 receptor tyrosine kinase 2 (ERBB2) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T14597-Ab-1, GM-Tg-hg-T14597-Ab-2,
GM-Tg-rg-T14597-Ab-1, GM-Tg-rg-T14597-Ab-2,
GM-Tg-mg-T14597-Ab-1, GM-Tg-mg-T14597-Ab-2,
GM-Tg-cynog-T14597-Ab-1, GM-Tg-cynog-T14597-Ab-2
Products NameAnti-HER2/ERBB2 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HER2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.