Human NPC1/NPC/ POGZ ORF/cDNA clone-Lentivirus plasmid (NM_000271.4)

Pre-made Human NPC1/NPC/ POGZ Lentiviral expression plasmid for NPC1 lentivirus packaging, NPC1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Target products collectionGo to NPC1/NPC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)



Product information

Catalog No. Product Name Plasmid Grade Plasmid quantity
pGMLV000463 Human NPC1 Lentivirus plasmid Research Grade 10mg, 50mg, 100mg, 500mg, >1g
GMP-like Grade 10mg, 50mg, 100mg, 500mg, >1g
High Quality (HQ) Grade
Seed 5ug


Product Description

Catalog ID pGMLV000463
Gene Name NPC1
Accession Number NM_000271.4
Gene ID 4864
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 3837 bp
Gene Alias NPC, POGZ, SLC65A1
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocinmyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-MP0896-Ab Anti-NPC1/ NPC/ POGZ monoclonal antibody
    Target Antigen GM-Tg-g-MP0896-Ag NPC1 VLP (virus-like particle)
    ORF Viral Vector pGMLV000454 Human NPC1 Lentivirus plasmid
    ORF Viral Vector pGMLV000463 Human NPC1 Lentivirus plasmid
    ORF Viral Vector vGMLV000454 Human NPC1 Lentivirus particle
    ORF Viral Vector vGMLV000463 Human NPC1 Lentivirus particle


    Target information

    Target ID GM-MP0896
    Target Name NPC1
    Gene ID 4864, 18145, 700835, 266732, 493693, 403698, 286772, 100059175
    Gene Symbol and Synonyms A430089E03Rik,Cdig2,D18Ertd139e,D18Ertd723e,lcsd,nmf164,NPC,NPC1,POGZ,SLC65A1,SLC66A1,spm
    Uniprot Accession O15118
    Uniprot Entry Name NPC1_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Not Available
    Disease Not Available
    Gene Ensembl ENSG00000141458
    Target Classification Not Available

    This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]



    About GMVC

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    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.