Human USP2/UBP41/USP9 ORF/cDNA clone-Lentivirus plasmid (NM_004205.4)

Cat. No.: pGMLV000588
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human USP2/UBP41/USP9 Lentiviral expression plasmid for USP2 lentivirus packaging, USP2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLV000588
Gene Name USP2
Accession Number NM_004205.4
Gene ID 9099
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 1818 bp
Gene Alias UBP41,USP9
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGTCCCAGCTCTCCTCCACCCTGAAGCGCTACACAGAATCGGCCCGCTACACAGATGCCCACTATGCCAAGTCGGGCTATGGTGCCTACACCCCGTCCTCCTATGGGGCCAATCTGGCTGCCTCCTTACTGGAGAAGGAGAAACTTGGTTTCAAGCCGGTCCCCACCAGCAGCTTCCTCACCCGTCCCCGTACCTATGGCCCCTCCTCCCTCCTGGACTATGACCGGGGCCGCCCCCTGCTGAGACCCGACATCACTGGGGGTGGTAAGCGGGCAGAGAGCCAGACCCGGGGTACTGAGCGGCCTTTAGGCAGTGGCCTCAGCGGGGGCAGCGGATTCCCTTATGGAGTGACCAACAACTGCCTCAGCTACCTGCCCATCAATGCCTATGACCAGGGGGTGACCCTAACCCAGAAGCTGGACAGCCAATCAGACCTGGCCCGGGATTTCTCCAGCCTCCGGACCTCAGATAGCTACCGGATAGACCCCAGGAACCTGGGCCGCAGCCCCATGCTGGCCCGGACGCGCAAGGAGCTCTGCACCCTGCAGGGGCTCTACCAGACAGCCAGCTGCCCTGAATACCTGGTCGACTACCTGGAGAACTATGGTCGCAAGGGCAGTGCATCTCAGGTGCCCTCCCAGGCCCCTCCCTCACGAGTCCCTGAAATCATCAGCCCAACCTACCGACCCATTGGCCGCTACACGCTGTGGGAGACGGGAAAGGGTCAGGCCCCTGGGCCCAGCCGCTCCAGCTCCCCGGGAAGAGACGGCATGAATTCTAAGAGTGCCCAGGGTCTGGCTGGTCTTCGAAACCTTGGGAACACGTGCTTCATGAACTCAATTCTGCAGTGCCTGAGCAACACTCGGGAGTTGAGAGATTACTGCCTCCAGAGGCTCTACATGCGGGACCTGCACCACGGCAGCAATGCACACACAGCCCTCGTGGAAGAGTTTGCAAAACTAATTCAGACCATATGGACTTCATCCCCCAATGATGTGGTGAGCCCATCTGAGTTCAAGACCCAGATCCAGAGATACGCACCGCGCTTTGTTGGCTATAATCAGCAGGATGCTCAGGAGTTCCTTCGCTTTCTTCTGGATGGGCTCCATAACGAGGTGAACCGAGTGACACTGAGACCTAAGTCCAACCCTGAGAACCTCGATCATCTTCCTGATGACGAGAAAGGCCGACAGATGTGGAGAAAATATCTAGAACGGGAAGACAGTAGGATCGGGGATCTCTTTGTTGGGCAGCTAAAGAGCTCGCTGACGTGTACAGATTGTGGTTACTGTTCTACGGTCTTCGACCCCTTCTGGGACCTCTCACTGCCCATTGCTAAGCGAGGTTATCCTGAGGTGACATTAATGGACTGCATGAGGCTCTTCACCAAAGAGGATGTGCTTGATGGAGATGAAAAGCCAACATGCTGTCGCTGCCGAGGCAGAAAACGGTGTATAAAGAAGTTCTCCATCCAGAGGTTCCCAAAGATCTTGGTGCTCCATCTGAAGCGGTTCTCAGAATCCAGGATCCGAACCAGCAAGCTCACAACATTTGTGAACTTCCCCCTAAGAGACCTGGACTTAAGAGAATTTGCCTCAGAAAACACCAACCATGCTGTTTACAACCTGTACGCTGTGTCCAATCACTCCGGAACCACCATGGGTGGCCACTATACAGCCTACTGTCGCAGTCCAGGGACAGGAGAATGGCACACTTTCAACGACTCCAGCGTCACTCCCATGTCCTCCAGCCAAGTGCGCACCAGCGACGCCTACCTGCTCTTCTACGAACTGGCCAGCCCGCCCTCCCGAATGTAG
ORF Protein Sequence MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-IP0120-Ab Anti-USP2 monoclonal antibody
    Target Antigen GM-Tg-g-IP0120-Ag USP2 protein
    ORF Viral Vector pGMLP002347 Human USP2 Lentivirus plasmid
    ORF Viral Vector pGMLV000588 Human USP2 Lentivirus plasmid
    ORF Viral Vector vGMLP002347 Human USP2 Lentivirus particle
    ORF Viral Vector vGMLV000588 Human USP2 Lentivirus particle


    Target information

    Target ID GM-IP0120
    Target Name USP2
    Gene ID 9099, 53376, 705191, 115771, 101097757, 608188, 522980
    Gene Symbol and Synonyms B930035K21Rik,UBP-t,UBP41,USP2,USP9
    Uniprot Accession O75604
    Uniprot Entry Name UBP2_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000036672
    Target Classification Not Available

    This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]



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