Human CCND1/BCL1/D11S287E ORF/cDNA clone-Lentivirus particle (NM_053056.2)

Cat. No.: vGMLV000042

Pre-made Human CCND1/BCL1/D11S287E Lentiviral expression plasmid for CCND1 lentivirus packaging, CCND1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLV000042 Human CCND1 Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLV000042
Gene Name CCND1
Accession Number NM_053056.2
Gene ID 595
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 888 bp
Gene Alias BCL1,D11S287E,PRAD1,U21B31
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCGCGCGTACCCCGATGCCAACCTCCTCAACGACCGGGTGCTGCGGGCCATGCTGAAGGCGGAGGAGACCTGCGCGCCCTCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTCCATGCGGAAGATCGTCGCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGAGGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAAGAGCCGCCTGCAGCTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACGGCCGAGAAGCTGTGCATCTACACCGACAACTCCATCCGGCCCGAGGAGCTGCTGCAAATGGAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTCATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGAGGAGAACAAACAGATCATCCGCAAACACGCGCAGACCTTCGTTGCCCTCTGTGCCACAGATGTGAAGTTCATTTCCAATCCGCCCTCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCCAACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGACCCGGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGTCAAGCCTGCGCCAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAGGTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGA
ORF Protein Sequence MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T12355-Ab Anti-CCND1 monoclonal antibody
    Target Antigen GM-Tg-g-T12355-Ag CCND1 protein
    ORF Viral Vector pGMLP005612 Human CCND1 Lentivirus plasmid
    ORF Viral Vector pGMLV000042 Human CCND1 Lentivirus plasmid
    ORF Viral Vector pGMLV000670 Human CCND1 Lentivirus plasmid
    ORF Viral Vector pGMLV002266 Human CCND1 Lentivirus plasmid
    ORF Viral Vector pGMAP000562 Human CCND1 Adenovirus plasmid
    ORF Viral Vector pGMPC000006 Human CCND1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC000351 Human CCND1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP005612 Human CCND1 Lentivirus particle
    ORF Viral Vector vGMLV000042 Human CCND1 Lentivirus particle
    ORF Viral Vector vGMLV000670 Human CCND1 Lentivirus particle
    ORF Viral Vector vGMLV002266 Human CCND1 Lentivirus particle
    ORF Viral Vector vGMAP000562 Human CCND1 Adenovirus particle


    Target information

    Target ID GM-T12355
    Target Name CCND1
    Gene ID 595, 12443, 574320, 58919, 100037407, 449028, 524530, 102149114
    Gene Symbol and Synonyms bcl-1,BCL1,CCND1,cD1,CycD1,Cyl-1,D11S287E,PRAD1,U21B31
    Uniprot Accession P24385
    Uniprot Entry Name CCND1_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Breast Cancer, Head and neck squamous cell carcinoma (HNSCC), tumor, Cancer, Breast cancer
    Gene Ensembl ENSG00000110092
    Target Classification Not Available

    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]



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