Human CDKN1A/CAP20/CDKN1 ORF/cDNA clone-Lentivirus particle (NM_000389.5)

Cat. No.: vGMLV001624

Pre-made Human CDKN1A/CAP20/CDKN1 Lentiviral expression plasmid for CDKN1A lentivirus packaging, CDKN1A lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLV001624 Human CDKN1A Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLV001624
Gene Name CDKN1A
Accession Number NM_000389.5
Gene ID 1026
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 495 bp
Gene Alias CAP20,CDKN1,CIP1,MDA-6,P21,p21CIP1,SDI1,WAF1
Fluorescent Reporter mCherry
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGTCAGAACCGGCTGGGGATGTCCGTCAGAACCCATGCGGCAGCAAGGCCTGCCGCCGCCTCTTCGGCCCAGTGGACAGCGAGCAGCTGAGCCGCGACTGTGATGCGCTAATGGCGGGCTGCATCCAGGAGGCCCGTGAGCGATGGAACTTCGACTTTGTCACCGAGACACCACTGGAGGGTGACTTCGCCTGGGAGCGTGTGCGGGGCCTTGGCCTGCCCAAGCTCTACCTTCCCACGGGGCCCCGGCGAGGCCGGGATGAGTTGGGAGGAGGCAGGCGGCCTGGCACCTCACCTGCTCTGCTGCAGGGGACAGCAGAGGAAGACCATGTGGACCTGTCACTGTCTTGTACCCTTGTGCCTCGCTCAGGGGAGCAGGCTGAAGGGTCCCCAGGTGGACCTGGAGACTCTCAGGGTCGAAAACGGCGGCAGACCAGCATGACAGATTTCTACCACTCCAAACGCCGGCTGATCTTCTCCAAGAGGAAGCCCTAA
ORF Protein Sequence MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T39855-Ab Anti-CDKN1A monoclonal antibody
    Target Antigen GM-Tg-g-T39855-Ag CDKN1A protein
    ORF Viral Vector pGMLV001624 Human CDKN1A Lentivirus plasmid
    ORF Viral Vector pGMAP000096 Human CDKN1A Adenovirus plasmid
    ORF Viral Vector pGMPC000071 Human CDKN1A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV001624 Human CDKN1A Lentivirus particle
    ORF Viral Vector vGMAP000096 Human CDKN1A Adenovirus particle


    Target information

    Target ID GM-T39855
    Target Name CDKN1A
    Gene ID 1026, 12575, 719199, 114851, 493943, 474890, 513497, 100064022
    Gene Symbol and Synonyms CAP20,CDKI,CDKN1,CDKN1A,CIP1,MDA-6,mda6,P21,p21CIP1,p21WAF,SDI1,UV96,WAF1
    Uniprot Accession P38936
    Uniprot Entry Name CDN1A_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Prostate Cancer
    Gene Ensembl ENSG00000124762
    Target Classification Not Available

    This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]



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