Human EIF4E/AUTS19/CBP ORF/cDNA clone-Lentivirus particle (NM_001130679.2)

Cat. No.: vGMLV001692

Pre-made Human EIF4E/AUTS19/CBP Lentiviral expression plasmid for EIF4E lentivirus packaging, EIF4E lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLV001692 Human EIF4E Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLV001692
Gene Name EIF4E
Accession Number NM_001130679.2
Gene ID 1977
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 747 bp
Gene Alias AUTS19,CBP,eIF-4E,EIF4E1,EIF4EL1,EIF4F
Fluorescent Reporter Null
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGCGACTGTCGAACCGGAAACCACCCCTACTCCTAATCCCCCGACTACAGAAGAGGAGAAAACGGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGATGGGCACTCTGGTTTTTTAAAAATGATAAAAGCAAAACTTGGCAAGCAAACCTGCGGCTGATCTCCAAGTTTGATACTGTTGAAGACTTTTGGGCTCTGTACAACCATATCCAGTTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGATGGTATTGAGCCTATGTGGGAAGATGAGAAAAACAAACGGGGAGGACGATGGCTAATTACATTGAACAAACAGCAGAGACGAAGTGACCTCGATCGCTTTTGGCTAGAGACAAGATGGGATCTTGCTATGTTGCCCAGGTTGGTCTCAAACTTCTGGCCTCAAGTGATCCTCCCACTTCAGCCTCCCAAAGTGCTGGAATTACAGCTTCTGTGCCTTATTGGAGAATCTTTTGATGACTACAGTGATGATGTATGTGGCGCTGTTGTTAATGTTAGAGCTAAAGGTGATAAGATAGCAATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATAGGGAGGGTATACAAGGAAAGGTTAGGACTTCCTCCAAAGATAGTGATTGGTTATCAGTCCCACGCAGACACAGCTACTAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAA
ORF Protein Sequence MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETRWDLAMLPRLVSNFWPQVILPLQPPKVLELQLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T31186-Ab Anti-EIF4E monoclonal antibody
    Target Antigen GM-Tg-g-T31186-Ag EIF4E protein
    ORF Viral Vector pGMLP004795 Human EIF4E Lentivirus plasmid
    ORF Viral Vector pGMLV000782 Human EIF4E Lentivirus plasmid
    ORF Viral Vector pGMLV001692 Human EIF4E Lentivirus plasmid
    ORF Viral Vector vGMLP004795 Human EIF4E Lentivirus particle
    ORF Viral Vector vGMLV000782 Human EIF4E Lentivirus particle
    ORF Viral Vector vGMLV001692 Human EIF4E Lentivirus particle


    Target information

    Target ID GM-T31186
    Target Name EIF4E
    Gene ID 1977, 13684, 706751, 117045, 101080377, 487870, 281751, 100066216
    Gene Symbol and Synonyms AUTS19,CBP,EG668879,eIF-4E,EIF4E,Eif4e-ps,EIF4E1,EIF4EL1,EIF4F,If4e
    Uniprot Accession P06730
    Uniprot Entry Name IF4E_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000151247
    Target Classification Tumor-associated antigen (TAA)

    The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]



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