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Anti-IGHE monoclonal antibody
Pre-made anti-IGHE monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to IGHE/IGHE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-INN002-Ab-1/ GM-Tg-hg-INN002-Ab-2 | Anti-Human IGHE monoclonal antibody | Human |
| GM-Tg-rg-INN002-Ab-1/ GM-Tg-rg-INN002-Ab-2 | Anti-Rat IGHE monoclonal antibody | Rat |
| GM-Tg-mg-INN002-Ab-1/ GM-Tg-mg-INN002-Ab-2 | Anti-Mouse IGHE monoclonal antibody | Mouse |
| GM-Tg-cynog-INN002-Ab-1/ GM-Tg-cynog-INN002-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGHE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-INN002-Ab-1/ GM-Tg-felg-INN002-Ab-2 | Anti-Feline IGHE monoclonal antibody | Feline |
| GM-Tg-cang-INN002-Ab-1/ GM-Tg-cang-INN002-Ab-2 | Anti-Canine IGHE monoclonal antibody | Canine |
| GM-Tg-bovg-INN002-Ab-1/ GM-Tg-bovg-INN002-Ab-2 | Anti-Bovine IGHE monoclonal antibody | Bovine |
| GM-Tg-equg-INN002-Ab-1/ GM-Tg-equg-INN002-Ab-2 | Anti-Equine IGHE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-INN002-Ab-1/ GM-Tg-hg-INN002-Ab-2; GM-Tg-rg-INN002-Ab-1/ GM-Tg-rg-INN002-Ab-2; GM-Tg-mg-INN002-Ab-1/ GM-Tg-mg-INN002-Ab-2; GM-Tg-cynog-INN002-Ab-1/ GM-Tg-cynog-INN002-Ab-2; GM-Tg-felg-INN002-Ab-1/ GM-Tg-felg-INN002-Ab-2; GM-Tg-cang-INN002-Ab-1/ GM-Tg-cang-INN002-Ab-2; GM-Tg-bovg-INN002-Ab-1/ GM-Tg-bovg-INN002-Ab-2; GM-Tg-equg-INN002-Ab-1/ GM-Tg-equg-INN002-Ab-2 |
| Products Name | Anti-IGHE monoclonal antibody |
| Format | mab |
| Target Name | IGHE |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-IGHE monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-398 | Pre-Made Omalizumab biosimilar, Whole Mab: Anti-IGHE/IgE therapeutic antibody |
| Biosimilar | GMP-Bios-ab-462 | Pre-Made Quilizumab biosimilar, Whole Mab: Anti-IGHE/IgE therapeutic antibody |
| Biosimilar | GMP-Bios-ab-312 | Pre-Made Ligelizumab biosimilar, Whole Mab: Anti-IGHE/IgE therapeutic antibody |
| Biosimilar | GMP-Bios-INN-1005 | Pre-Made Talizumab Biosimilar, Whole Mab: Anti-Ighe/IgE therapeutic antibody |
| Target Antigen | GM-Tg-g-INN002-Ag-1 | Recombinant multi-species IGHE/ IgE protein |
Target information
| Target ID | GM-INN002 |
| Target Name | IGHE |
| Gene ID | 3497 |
| Gene Symbol and Synonyms | IgE,IGHE |
| Uniprot Accession | P01854 |
| Uniprot Entry Name | IGHE_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000211891 |
| Target Classification | N/A |
The target: IGHE, gene name: IGHE, also named as IgE. Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be located in extracellular region. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
