Anti-PERK monoclonal antibody
Pre-made anti-PERK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PERK/EIF2AK3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-IP0003-Ab-1/ GM-Tg-hg-IP0003-Ab-2 | Anti-Human PERK/EIF2AK3 monoclonal antibody | Human |
GM-Tg-rg-IP0003-Ab-1/ GM-Tg-rg-IP0003-Ab-2 | Anti-Rat PERK/EIF2AK3 monoclonal antibody | Rat |
GM-Tg-mg-IP0003-Ab-1/ GM-Tg-mg-IP0003-Ab-2 | Anti-Mouse PERK/EIF2AK3 monoclonal antibody | Mouse |
GM-Tg-cynog-IP0003-Ab-1/ GM-Tg-cynog-IP0003-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PERK/EIF2AK3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-IP0003-Ab-1/ GM-Tg-felg-IP0003-Ab-2 | Anti-Feline PERK/EIF2AK3 monoclonal antibody | Feline |
GM-Tg-cang-IP0003-Ab-1/ GM-Tg-cang-IP0003-Ab-2 | Anti-Canine PERK/EIF2AK3 monoclonal antibody | Canine |
GM-Tg-bovg-IP0003-Ab-1/ GM-Tg-bovg-IP0003-Ab-2 | Anti-Bovine PERK/EIF2AK3 monoclonal antibody | Bovine |
GM-Tg-equg-IP0003-Ab-1/ GM-Tg-equg-IP0003-Ab-2 | Anti-Equine PERK/EIF2AK3 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-IP0003-Ab-1/ GM-Tg-hg-IP0003-Ab-2; GM-Tg-rg-IP0003-Ab-1/ GM-Tg-rg-IP0003-Ab-2; GM-Tg-mg-IP0003-Ab-1/ GM-Tg-mg-IP0003-Ab-2; GM-Tg-cynog-IP0003-Ab-1/ GM-Tg-cynog-IP0003-Ab-2; GM-Tg-felg-IP0003-Ab-1/ GM-Tg-felg-IP0003-Ab-2; GM-Tg-cang-IP0003-Ab-1/ GM-Tg-cang-IP0003-Ab-2; GM-Tg-bovg-IP0003-Ab-1/ GM-Tg-bovg-IP0003-Ab-2; GM-Tg-equg-IP0003-Ab-1/ GM-Tg-equg-IP0003-Ab-2 |
Products Name | Anti-PERK/EIF2AK3 monoclonal antibody |
Format | mab |
Target Name | PERK |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-PERK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-IP0003-Ag-1 | Recombinant multi-species E2AK3/ PERK/ EIF2AK3 protein |
Target information
Target ID | GM-IP0003 |
Target Name | PERK |
Gene ID | 9451,13666,29702,699575,475756,101095973,535820,100066488 |
Gene Symbol and Synonyms | EIF2AK3,PEK,PERK,WRS |
Uniprot Accession | Q9NZJ5,Q9Z1Z1 |
Uniprot Entry Name | E2AK3_HUMAN,E2AK3_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | N/A |
Gene Ensembl | ENSG00000172071 |
Target Classification | Checkpoint-Immuno Oncology |
The target: PERK, gene name: EIF2AK3, also named as PEK, PERK, WRS. The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.