Anti-CYP3A4 monoclonal antibody

Pre-made anti-CYP3A4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to CYP3A4/CYP3A4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0038-Ab-1/ GM-Tg-hg-IP0038-Ab-2Anti-Human CYP3A4 monoclonal antibodyHuman
GM-Tg-rg-IP0038-Ab-1/ GM-Tg-rg-IP0038-Ab-2Anti-Rat CYP3A4 monoclonal antibodyRat
GM-Tg-mg-IP0038-Ab-1/ GM-Tg-mg-IP0038-Ab-2Anti-Mouse CYP3A4 monoclonal antibodyMouse
GM-Tg-cynog-IP0038-Ab-1/ GM-Tg-cynog-IP0038-Ab-2Anti-Cynomolgus/ Rhesus macaque CYP3A4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0038-Ab-1/ GM-Tg-felg-IP0038-Ab-2Anti-Feline CYP3A4 monoclonal antibodyFeline
GM-Tg-cang-IP0038-Ab-1/ GM-Tg-cang-IP0038-Ab-2Anti-Canine CYP3A4 monoclonal antibodyCanine
GM-Tg-bovg-IP0038-Ab-1/ GM-Tg-bovg-IP0038-Ab-2Anti-Bovine CYP3A4 monoclonal antibodyBovine
GM-Tg-equg-IP0038-Ab-1/ GM-Tg-equg-IP0038-Ab-2Anti-Equine CYP3A4 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0038-Ab-1/ GM-Tg-hg-IP0038-Ab-2; GM-Tg-rg-IP0038-Ab-1/ GM-Tg-rg-IP0038-Ab-2;
GM-Tg-mg-IP0038-Ab-1/ GM-Tg-mg-IP0038-Ab-2; GM-Tg-cynog-IP0038-Ab-1/ GM-Tg-cynog-IP0038-Ab-2;
GM-Tg-felg-IP0038-Ab-1/ GM-Tg-felg-IP0038-Ab-2; GM-Tg-cang-IP0038-Ab-1/ GM-Tg-cang-IP0038-Ab-2;
GM-Tg-bovg-IP0038-Ab-1/ GM-Tg-bovg-IP0038-Ab-2; GM-Tg-equg-IP0038-Ab-1/ GM-Tg-equg-IP0038-Ab-2
Products NameAnti-CYP3A4 monoclonal antibody
Formatmab
Target NameCYP3A4
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-CYP3A4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0038-Ag-1Recombinant multi-species CP3A4/ CYP3A4/ CP33 protein
    ORF Viral VectorvGMAP000372Human CYP3A4 Adenovirus particle
    ORF Viral VectorpGMAP000372Human CYP3A4 Adenovirus plasmid


    Target information

    Target IDGM-IP0038
    Target NameCYP3A4
    Gene ID1576
    Gene Symbol and SynonymsCP33,CP34,CYP3A,CYP3A3,CYP3A4,CYPIIIA3,CYPIIIA4,HLP,NF-25,P450C3,P450PCN1,VDDR3
    Uniprot AccessionP08684
    Uniprot Entry NameCP3A4_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000160868
    Target ClassificationTumor-associated antigen (TAA)

    The target: CYP3A4, gene name: CYP3A4, also named as CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.