Anti-PDE4B monoclonal antibody

Pre-made anti-PDE4B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PDE4B/PDE4B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0041-Ab-1/ GM-Tg-hg-IP0041-Ab-2Anti-Human PDE4B monoclonal antibodyHuman
GM-Tg-rg-IP0041-Ab-1/ GM-Tg-rg-IP0041-Ab-2Anti-Rat PDE4B monoclonal antibodyRat
GM-Tg-mg-IP0041-Ab-1/ GM-Tg-mg-IP0041-Ab-2Anti-Mouse PDE4B monoclonal antibodyMouse
GM-Tg-cynog-IP0041-Ab-1/ GM-Tg-cynog-IP0041-Ab-2Anti-Cynomolgus/ Rhesus macaque PDE4B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0041-Ab-1/ GM-Tg-felg-IP0041-Ab-2Anti-Feline PDE4B monoclonal antibodyFeline
GM-Tg-cang-IP0041-Ab-1/ GM-Tg-cang-IP0041-Ab-2Anti-Canine PDE4B monoclonal antibodyCanine
GM-Tg-bovg-IP0041-Ab-1/ GM-Tg-bovg-IP0041-Ab-2Anti-Bovine PDE4B monoclonal antibodyBovine
GM-Tg-equg-IP0041-Ab-1/ GM-Tg-equg-IP0041-Ab-2Anti-Equine PDE4B monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0041-Ab-1/ GM-Tg-hg-IP0041-Ab-2; GM-Tg-rg-IP0041-Ab-1/ GM-Tg-rg-IP0041-Ab-2;
GM-Tg-mg-IP0041-Ab-1/ GM-Tg-mg-IP0041-Ab-2; GM-Tg-cynog-IP0041-Ab-1/ GM-Tg-cynog-IP0041-Ab-2;
GM-Tg-felg-IP0041-Ab-1/ GM-Tg-felg-IP0041-Ab-2; GM-Tg-cang-IP0041-Ab-1/ GM-Tg-cang-IP0041-Ab-2;
GM-Tg-bovg-IP0041-Ab-1/ GM-Tg-bovg-IP0041-Ab-2; GM-Tg-equg-IP0041-Ab-1/ GM-Tg-equg-IP0041-Ab-2
Products NameAnti-PDE4B monoclonal antibody
Formatmab
Target NamePDE4B
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PDE4B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0041-Ag-1Recombinant multi-species PDE4B/ DPDE4/ PDEIVB protein
    ORF Viral VectorpGMAAV000224house mouse Pde4b AAV plasmid
    ORF Viral VectorvGMAAV000224house mouse Pde4b AAV particle


    Target information

    Target IDGM-IP0041
    Target NamePDE4B
    Gene ID5142,18578,24626,699309,479540,101081316,100124505,100053961
    Gene Symbol and SynonymsDPDE4,dunce,PDE4/IVb,PDE4B,Pde4B1,Pde4B2,Pde4B3,Pde4B4,Pde4b5,Pde4b_v1,Pde4b_v2,Pde4b_v3,Pde4b_v4,PDEIVB
    Uniprot AccessionQ07343,P14646
    Uniprot Entry NamePDE4B_HUMAN,PDE4B_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000184588
    Target ClassificationN/A

    The target: PDE4B, gene name: PDE4B, also named as DPDE4, PDEIVB. This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.