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Anti-ESPL1 monoclonal antibody
Pre-made anti-ESPL1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ESPL1/ESPL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0771-Ab-1/ GM-Tg-hg-IP0771-Ab-2 | Anti-Human ESPL1 monoclonal antibody | Human |
| GM-Tg-rg-IP0771-Ab-1/ GM-Tg-rg-IP0771-Ab-2 | Anti-Rat ESPL1 monoclonal antibody | Rat |
| GM-Tg-mg-IP0771-Ab-1/ GM-Tg-mg-IP0771-Ab-2 | Anti-Mouse ESPL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0771-Ab-1/ GM-Tg-cynog-IP0771-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ESPL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0771-Ab-1/ GM-Tg-felg-IP0771-Ab-2 | Anti-Feline ESPL1 monoclonal antibody | Feline |
| GM-Tg-cang-IP0771-Ab-1/ GM-Tg-cang-IP0771-Ab-2 | Anti-Canine ESPL1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0771-Ab-1/ GM-Tg-bovg-IP0771-Ab-2 | Anti-Bovine ESPL1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0771-Ab-1/ GM-Tg-equg-IP0771-Ab-2 | Anti-Equine ESPL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0771-Ab-1/ GM-Tg-hg-IP0771-Ab-2; GM-Tg-rg-IP0771-Ab-1/ GM-Tg-rg-IP0771-Ab-2; GM-Tg-mg-IP0771-Ab-1/ GM-Tg-mg-IP0771-Ab-2; GM-Tg-cynog-IP0771-Ab-1/ GM-Tg-cynog-IP0771-Ab-2; GM-Tg-felg-IP0771-Ab-1/ GM-Tg-felg-IP0771-Ab-2; GM-Tg-cang-IP0771-Ab-1/ GM-Tg-cang-IP0771-Ab-2; GM-Tg-bovg-IP0771-Ab-1/ GM-Tg-bovg-IP0771-Ab-2; GM-Tg-equg-IP0771-Ab-1/ GM-Tg-equg-IP0771-Ab-2 |
| Products Name | Anti-ESPL1 monoclonal antibody |
| Format | mab |
| Target Name | ESPL1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ESPL1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0771-Ag-1 | Recombinant multi-species ESPL1/ ESP1/ SEPA protein |
Target information
| Target ID | GM-IP0771 |
| Target Name | ESPL1 |
| Gene ID | 9700,105988,315330,702136,607879,101084118,506740,100063779 |
| Gene Symbol and Synonyms | Cerp,ESP1,ESPL1,PRCE,SEPA,separin,SSE |
| Uniprot Accession | Q14674 |
| Uniprot Entry Name | ESPL1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000135476 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ESPL1, gene name: ESPL1, also named as ESP1, SEPA. Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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