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Anti-FBXW12 monoclonal antibody
Pre-made anti-FBXW12 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FBXW12/FBXW12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0838-Ab-1/ GM-Tg-hg-IP0838-Ab-2 | Anti-Human FBXW12 monoclonal antibody | Human |
| GM-Tg-rg-IP0838-Ab-1/ GM-Tg-rg-IP0838-Ab-2 | Anti-Rat FBXW12 monoclonal antibody | Rat |
| GM-Tg-mg-IP0838-Ab-1/ GM-Tg-mg-IP0838-Ab-2 | Anti-Mouse FBXW12 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0838-Ab-1/ GM-Tg-cynog-IP0838-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FBXW12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0838-Ab-1/ GM-Tg-felg-IP0838-Ab-2 | Anti-Feline FBXW12 monoclonal antibody | Feline |
| GM-Tg-cang-IP0838-Ab-1/ GM-Tg-cang-IP0838-Ab-2 | Anti-Canine FBXW12 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0838-Ab-1/ GM-Tg-bovg-IP0838-Ab-2 | Anti-Bovine FBXW12 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0838-Ab-1/ GM-Tg-equg-IP0838-Ab-2 | Anti-Equine FBXW12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0838-Ab-1/ GM-Tg-hg-IP0838-Ab-2; GM-Tg-rg-IP0838-Ab-1/ GM-Tg-rg-IP0838-Ab-2; GM-Tg-mg-IP0838-Ab-1/ GM-Tg-mg-IP0838-Ab-2; GM-Tg-cynog-IP0838-Ab-1/ GM-Tg-cynog-IP0838-Ab-2; GM-Tg-felg-IP0838-Ab-1/ GM-Tg-felg-IP0838-Ab-2; GM-Tg-cang-IP0838-Ab-1/ GM-Tg-cang-IP0838-Ab-2; GM-Tg-bovg-IP0838-Ab-1/ GM-Tg-bovg-IP0838-Ab-2; GM-Tg-equg-IP0838-Ab-1/ GM-Tg-equg-IP0838-Ab-2 |
| Products Name | Anti-FBXW12 monoclonal antibody |
| Format | mab |
| Target Name | FBXW12 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FBXW12 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0838-Ag-1 | Recombinant multi-species FBW12/ FBXW12/ FBXO12 protein |
Target information
| Target ID | GM-IP0838 |
| Target Name | FBXW12 |
| Gene ID | 285231,301015,100429515,484779,101087138,102150555 |
| Gene Symbol and Synonyms | FBW12,FBXO12,FBXO35,FBXW12,RGD1307859 |
| Uniprot Accession | Q6X9E4 |
| Uniprot Entry Name | FBW12_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000164049 |
| Target Classification | N/A |
The target: FBXW12, gene name: FBXW12, also named as FBW12, FBXO12, FBXO35. Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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