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Anti-HLA-DMA monoclonal antibody
Pre-made anti-HLA-DMA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HLA-DMA/HLA-DMA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0970-Ab-1/ GM-Tg-hg-IP0970-Ab-2 | Anti-Human HLA-DMA monoclonal antibody | Human |
| GM-Tg-rg-IP0970-Ab-1/ GM-Tg-rg-IP0970-Ab-2 | Anti-Rat HLA-DMA monoclonal antibody | Rat |
| GM-Tg-mg-IP0970-Ab-1/ GM-Tg-mg-IP0970-Ab-2 | Anti-Mouse HLA-DMA monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0970-Ab-1/ GM-Tg-cynog-IP0970-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HLA-DMA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0970-Ab-1/ GM-Tg-felg-IP0970-Ab-2 | Anti-Feline HLA-DMA monoclonal antibody | Feline |
| GM-Tg-cang-IP0970-Ab-1/ GM-Tg-cang-IP0970-Ab-2 | Anti-Canine HLA-DMA monoclonal antibody | Canine |
| GM-Tg-bovg-IP0970-Ab-1/ GM-Tg-bovg-IP0970-Ab-2 | Anti-Bovine HLA-DMA monoclonal antibody | Bovine |
| GM-Tg-equg-IP0970-Ab-1/ GM-Tg-equg-IP0970-Ab-2 | Anti-Equine HLA-DMA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0970-Ab-1/ GM-Tg-hg-IP0970-Ab-2; GM-Tg-rg-IP0970-Ab-1/ GM-Tg-rg-IP0970-Ab-2; GM-Tg-mg-IP0970-Ab-1/ GM-Tg-mg-IP0970-Ab-2; GM-Tg-cynog-IP0970-Ab-1/ GM-Tg-cynog-IP0970-Ab-2; GM-Tg-felg-IP0970-Ab-1/ GM-Tg-felg-IP0970-Ab-2; GM-Tg-cang-IP0970-Ab-1/ GM-Tg-cang-IP0970-Ab-2; GM-Tg-bovg-IP0970-Ab-1/ GM-Tg-bovg-IP0970-Ab-2; GM-Tg-equg-IP0970-Ab-1/ GM-Tg-equg-IP0970-Ab-2 |
| Products Name | Anti-HLA-DMA monoclonal antibody |
| Format | mab |
| Target Name | HLA-DMA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HLA-DMA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0970-Ag-1 | Recombinant multi-species DMA/ HLA-DMA/ D6S222E protein |
| ORF Viral Vector | vGMLP002653 | human HLA-DMA Lentivirus particle |
| ORF Viral Vector | pGMLP002653 | human HLA-DMA Lentivirus plasmid |
Target information
| Target ID | GM-IP0970 |
| Target Name | HLA-DMA |
| Gene ID | 3108,14998,294274,717870,481732,111560443,282490,100061035 |
| Gene Symbol and Synonyms | BOLA-DMA,D6S222E,DLA-DMA,DMA,DMA1,H-2Ma,H2-DMa,H2-Ma,HLA-DMA,HLADM,LOC100061035,LOC111560443,MAMU-DMA,RING6,RT1-DMa,RT1.DMa,RT1.Ma |
| Uniprot Accession | P28067 |
| Uniprot Entry Name | DMA_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000204257 |
| Target Classification | N/A |
The target: HLA-DMA, gene name: HLA-DMA, also named as D6S222E, DMA, HLADM, RING6. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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