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Anti-HLA-DMB monoclonal antibody
Pre-made anti-HLA-DMB monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HLA-DMB/HLA-DMB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0971-Ab-1/ GM-Tg-hg-IP0971-Ab-2 | Anti-Human HLA-DMB monoclonal antibody | Human |
| GM-Tg-rg-IP0971-Ab-1/ GM-Tg-rg-IP0971-Ab-2 | Anti-Rat HLA-DMB monoclonal antibody | Rat |
| GM-Tg-mg-IP0971-Ab-1/ GM-Tg-mg-IP0971-Ab-2 | Anti-Mouse HLA-DMB monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0971-Ab-1/ GM-Tg-cynog-IP0971-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HLA-DMB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0971-Ab-1/ GM-Tg-felg-IP0971-Ab-2 | Anti-Feline HLA-DMB monoclonal antibody | Feline |
| GM-Tg-cang-IP0971-Ab-1/ GM-Tg-cang-IP0971-Ab-2 | Anti-Canine HLA-DMB monoclonal antibody | Canine |
| GM-Tg-bovg-IP0971-Ab-1/ GM-Tg-bovg-IP0971-Ab-2 | Anti-Bovine HLA-DMB monoclonal antibody | Bovine |
| GM-Tg-equg-IP0971-Ab-1/ GM-Tg-equg-IP0971-Ab-2 | Anti-Equine HLA-DMB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0971-Ab-1/ GM-Tg-hg-IP0971-Ab-2; GM-Tg-rg-IP0971-Ab-1/ GM-Tg-rg-IP0971-Ab-2; GM-Tg-mg-IP0971-Ab-1/ GM-Tg-mg-IP0971-Ab-2; GM-Tg-cynog-IP0971-Ab-1/ GM-Tg-cynog-IP0971-Ab-2; GM-Tg-felg-IP0971-Ab-1/ GM-Tg-felg-IP0971-Ab-2; GM-Tg-cang-IP0971-Ab-1/ GM-Tg-cang-IP0971-Ab-2; GM-Tg-bovg-IP0971-Ab-1/ GM-Tg-bovg-IP0971-Ab-2; GM-Tg-equg-IP0971-Ab-1/ GM-Tg-equg-IP0971-Ab-2 |
| Products Name | Anti-HLA-DMB monoclonal antibody |
| Format | mab |
| Target Name | HLA-DMB |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HLA-DMB monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0971-Ag-1 | Recombinant multi-species DMB/ HLA-DMB/ D6S221E protein |
| ORF Viral Vector | pGMLP003873 | human HLA-DMB Lentivirus plasmid |
| ORF Viral Vector | vGMLP002634 | human HLA-DMB Lentivirus particle |
| ORF Viral Vector | vGMLP003873 | human HLA-DMB Lentivirus particle |
| ORF Viral Vector | pGMLP002634 | human HLA-DMB Lentivirus plasmid |
Target information
| Target ID | GM-IP0971 |
| Target Name | HLA-DMB |
| Gene ID | 3109,15000,294273,100429857,607827,111556173,282491,100060996 |
| Gene Symbol and Synonyms | BOLA-DMB,D6S221E,DLA-DMB,DMb,H-2Mb2,H2-DMb2,H2-Mb2,HLA-DMB,LOC100060996,LOC111556173,MAMU-DMB,RING7,RT1-DMb,RT1.DMb,RT1.Mb |
| Uniprot Accession | P28068 |
| Uniprot Entry Name | DMB_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000242574 |
| Target Classification | N/A |
The target: HLA-DMB, gene name: HLA-DMB, also named as D6S221E, RING7. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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