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Anti-HRK monoclonal antibody
Pre-made anti-HRK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HRK/HRK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0981-Ab-1/ GM-Tg-hg-IP0981-Ab-2 | Anti-Human HRK monoclonal antibody | Human |
| GM-Tg-rg-IP0981-Ab-1/ GM-Tg-rg-IP0981-Ab-2 | Anti-Rat HRK monoclonal antibody | Rat |
| GM-Tg-mg-IP0981-Ab-1/ GM-Tg-mg-IP0981-Ab-2 | Anti-Mouse HRK monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0981-Ab-1/ GM-Tg-cynog-IP0981-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HRK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0981-Ab-1/ GM-Tg-felg-IP0981-Ab-2 | Anti-Feline HRK monoclonal antibody | Feline |
| GM-Tg-cang-IP0981-Ab-1/ GM-Tg-cang-IP0981-Ab-2 | Anti-Canine HRK monoclonal antibody | Canine |
| GM-Tg-bovg-IP0981-Ab-1/ GM-Tg-bovg-IP0981-Ab-2 | Anti-Bovine HRK monoclonal antibody | Bovine |
| GM-Tg-equg-IP0981-Ab-1/ GM-Tg-equg-IP0981-Ab-2 | Anti-Equine HRK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0981-Ab-1/ GM-Tg-hg-IP0981-Ab-2; GM-Tg-rg-IP0981-Ab-1/ GM-Tg-rg-IP0981-Ab-2; GM-Tg-mg-IP0981-Ab-1/ GM-Tg-mg-IP0981-Ab-2; GM-Tg-cynog-IP0981-Ab-1/ GM-Tg-cynog-IP0981-Ab-2; GM-Tg-felg-IP0981-Ab-1/ GM-Tg-felg-IP0981-Ab-2; GM-Tg-cang-IP0981-Ab-1/ GM-Tg-cang-IP0981-Ab-2; GM-Tg-bovg-IP0981-Ab-1/ GM-Tg-bovg-IP0981-Ab-2; GM-Tg-equg-IP0981-Ab-1/ GM-Tg-equg-IP0981-Ab-2 |
| Products Name | Anti-HRK monoclonal antibody |
| Format | mab |
| Target Name | HRK |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HRK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0981-Ag-1 | Recombinant multi-species HRK/ DP5/ HARAKIRI protein |
| ORF Viral Vector | pGMLP001870 | human HRK Lentivirus plasmid |
| ORF Viral Vector | vGMLP001870 | human HRK Lentivirus particle |
| ORF Viral Vector | pGMLPm004507 | mouse Hrk Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004507 | mouse Hrk Lentivirus particle |
Target information
| Target ID | GM-IP0981 |
| Target Name | HRK |
| Gene ID | 8739,12123,117271,107001036,612984,109493221,787139,100629981 |
| Gene Symbol and Synonyms | Bid3,DP5,HARAKIRI,HRK |
| Uniprot Accession | O00198,P62817 |
| Uniprot Entry Name | HRK_HUMAN,HRK_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000135116 |
| Target Classification | N/A |
The target: HRK, gene name: HRK, also named as DP5, HARAKIRI. This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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