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Anti-ICMT monoclonal antibody
Pre-made anti-ICMT monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ICMT/ICMT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0994-Ab-1/ GM-Tg-hg-IP0994-Ab-2 | Anti-Human ICMT monoclonal antibody | Human |
| GM-Tg-rg-IP0994-Ab-1/ GM-Tg-rg-IP0994-Ab-2 | Anti-Rat ICMT monoclonal antibody | Rat |
| GM-Tg-mg-IP0994-Ab-1/ GM-Tg-mg-IP0994-Ab-2 | Anti-Mouse ICMT monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0994-Ab-1/ GM-Tg-cynog-IP0994-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ICMT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0994-Ab-1/ GM-Tg-felg-IP0994-Ab-2 | Anti-Feline ICMT monoclonal antibody | Feline |
| GM-Tg-cang-IP0994-Ab-1/ GM-Tg-cang-IP0994-Ab-2 | Anti-Canine ICMT monoclonal antibody | Canine |
| GM-Tg-bovg-IP0994-Ab-1/ GM-Tg-bovg-IP0994-Ab-2 | Anti-Bovine ICMT monoclonal antibody | Bovine |
| GM-Tg-equg-IP0994-Ab-1/ GM-Tg-equg-IP0994-Ab-2 | Anti-Equine ICMT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0994-Ab-1/ GM-Tg-hg-IP0994-Ab-2; GM-Tg-rg-IP0994-Ab-1/ GM-Tg-rg-IP0994-Ab-2; GM-Tg-mg-IP0994-Ab-1/ GM-Tg-mg-IP0994-Ab-2; GM-Tg-cynog-IP0994-Ab-1/ GM-Tg-cynog-IP0994-Ab-2; GM-Tg-felg-IP0994-Ab-1/ GM-Tg-felg-IP0994-Ab-2; GM-Tg-cang-IP0994-Ab-1/ GM-Tg-cang-IP0994-Ab-2; GM-Tg-bovg-IP0994-Ab-1/ GM-Tg-bovg-IP0994-Ab-2; GM-Tg-equg-IP0994-Ab-1/ GM-Tg-equg-IP0994-Ab-2 |
| Products Name | Anti-ICMT monoclonal antibody |
| Format | mab |
| Target Name | ICMT |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ICMT monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0994-Ag-1 | Recombinant multi-species ICMT/ HSTE14/ MST098 protein |
| ORF Viral Vector | vGMLP004943 | human Icmt Lentivirus particle |
| ORF Viral Vector | pGMLP004943 | human Icmt Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002775 | mouse Icmt Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002775 | mouse Icmt Lentivirus particle |
Target information
| Target ID | GM-IP0994 |
| Target Name | ICMT |
| Gene ID | 23463,57295,170818,702925,489628,101093374,785548,100059680 |
| Gene Symbol and Synonyms | 1700008E11Rik,fcmt,Gm13095,HSTE14,ICMT,MST098,MSTP098,PCCMT,PCMT,PPMT,STE14 |
| Uniprot Accession | O60725,Q9WVM4 |
| Uniprot Entry Name | ICMT_HUMAN,ICMT_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000116237 |
| Target Classification | N/A |
The target: ICMT, gene name: ICMT, also named as HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT. This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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