- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-INSIG1 monoclonal antibody
Pre-made anti-INSIG1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to INSIG1/INSIG1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1014-Ab-1/ GM-Tg-hg-IP1014-Ab-2 | Anti-Human INSIG1 monoclonal antibody | Human |
| GM-Tg-rg-IP1014-Ab-1/ GM-Tg-rg-IP1014-Ab-2 | Anti-Rat INSIG1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1014-Ab-1/ GM-Tg-mg-IP1014-Ab-2 | Anti-Mouse INSIG1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1014-Ab-1/ GM-Tg-cynog-IP1014-Ab-2 | Anti-Cynomolgus/ Rhesus macaque INSIG1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1014-Ab-1/ GM-Tg-felg-IP1014-Ab-2 | Anti-Feline INSIG1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1014-Ab-1/ GM-Tg-cang-IP1014-Ab-2 | Anti-Canine INSIG1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1014-Ab-1/ GM-Tg-bovg-IP1014-Ab-2 | Anti-Bovine INSIG1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1014-Ab-1/ GM-Tg-equg-IP1014-Ab-2 | Anti-Equine INSIG1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1014-Ab-1/ GM-Tg-hg-IP1014-Ab-2; GM-Tg-rg-IP1014-Ab-1/ GM-Tg-rg-IP1014-Ab-2; GM-Tg-mg-IP1014-Ab-1/ GM-Tg-mg-IP1014-Ab-2; GM-Tg-cynog-IP1014-Ab-1/ GM-Tg-cynog-IP1014-Ab-2; GM-Tg-felg-IP1014-Ab-1/ GM-Tg-felg-IP1014-Ab-2; GM-Tg-cang-IP1014-Ab-1/ GM-Tg-cang-IP1014-Ab-2; GM-Tg-bovg-IP1014-Ab-1/ GM-Tg-bovg-IP1014-Ab-2; GM-Tg-equg-IP1014-Ab-1/ GM-Tg-equg-IP1014-Ab-2 |
| Products Name | Anti-INSIG1 monoclonal antibody |
| Format | mab |
| Target Name | INSIG1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-INSIG1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1014-Ag-1 | Recombinant multi-species INSI1/ INSIG1/ CL6 protein |
| ORF Viral Vector | pGMLP004574 | human INSIG1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004574 | human INSIG1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000930 | mouse Insig1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000930 | mouse Insig1 Lentivirus particle |
Target information
| Target ID | GM-IP1014 |
| Target Name | INSIG1 |
| Gene ID | 3638,231070,64194,718513,475554,101087651,511899,100065774 |
| Gene Symbol and Synonyms | 1810013C12Rik,CL6,Insig-1,INSIG1 |
| Uniprot Accession | O15503,Q08755,A0JNC3 |
| Uniprot Entry Name | INSI1_HUMAN,INSI1_RAT,INSI1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000186480 |
| Target Classification | N/A |
The target: INSIG1, gene name: INSIG1, also named as CL6. This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
