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Anti-INSIG2 monoclonal antibody
Pre-made anti-INSIG2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to INSIG2/INSIG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1015-Ab-1/ GM-Tg-hg-IP1015-Ab-2 | Anti-Human INSIG2 monoclonal antibody | Human |
| GM-Tg-rg-IP1015-Ab-1/ GM-Tg-rg-IP1015-Ab-2 | Anti-Rat INSIG2 monoclonal antibody | Rat |
| GM-Tg-mg-IP1015-Ab-1/ GM-Tg-mg-IP1015-Ab-2 | Anti-Mouse INSIG2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1015-Ab-1/ GM-Tg-cynog-IP1015-Ab-2 | Anti-Cynomolgus/ Rhesus macaque INSIG2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1015-Ab-1/ GM-Tg-felg-IP1015-Ab-2 | Anti-Feline INSIG2 monoclonal antibody | Feline |
| GM-Tg-cang-IP1015-Ab-1/ GM-Tg-cang-IP1015-Ab-2 | Anti-Canine INSIG2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1015-Ab-1/ GM-Tg-bovg-IP1015-Ab-2 | Anti-Bovine INSIG2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1015-Ab-1/ GM-Tg-equg-IP1015-Ab-2 | Anti-Equine INSIG2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1015-Ab-1/ GM-Tg-hg-IP1015-Ab-2; GM-Tg-rg-IP1015-Ab-1/ GM-Tg-rg-IP1015-Ab-2; GM-Tg-mg-IP1015-Ab-1/ GM-Tg-mg-IP1015-Ab-2; GM-Tg-cynog-IP1015-Ab-1/ GM-Tg-cynog-IP1015-Ab-2; GM-Tg-felg-IP1015-Ab-1/ GM-Tg-felg-IP1015-Ab-2; GM-Tg-cang-IP1015-Ab-1/ GM-Tg-cang-IP1015-Ab-2; GM-Tg-bovg-IP1015-Ab-1/ GM-Tg-bovg-IP1015-Ab-2; GM-Tg-equg-IP1015-Ab-1/ GM-Tg-equg-IP1015-Ab-2 |
| Products Name | Anti-INSIG2 monoclonal antibody |
| Format | mab |
| Target Name | INSIG2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-INSIG2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1015-Ag-1 | Recombinant multi-species INSI2/ INSIG2/ INSIG-2 protein |
| ORF Viral Vector | pGMLP002126 | human INSIG2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002126 | human INSIG2 Lentivirus particle |
| ORF Viral Vector | pGMLPm000931 | mouse Insig2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000931 | mouse Insig2 Lentivirus particle |
Target information
| Target ID | GM-IP1015 |
| Target Name | INSIG2 |
| Gene ID | 51141,72999,288985,693654,610496,101083870,534440,100049957 |
| Gene Symbol and Synonyms | 2900053I11Rik,C730043J18Rik,INSIG-2,INSIG2 |
| Uniprot Accession | Q9Y5U4,Q80UA9 |
| Uniprot Entry Name | INSI2_HUMAN,INSI2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000125629 |
| Target Classification | N/A |
The target: INSIG2, gene name: INSIG2, also named as INSIG-2. The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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