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Anti-MAL monoclonal antibody
Pre-made anti-MAL monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MAL/MAL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1136-Ab-1/ GM-Tg-hg-IP1136-Ab-2 | Anti-Human MAL monoclonal antibody | Human |
| GM-Tg-rg-IP1136-Ab-1/ GM-Tg-rg-IP1136-Ab-2 | Anti-Rat MAL monoclonal antibody | Rat |
| GM-Tg-mg-IP1136-Ab-1/ GM-Tg-mg-IP1136-Ab-2 | Anti-Mouse MAL monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1136-Ab-1/ GM-Tg-cynog-IP1136-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MAL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1136-Ab-1/ GM-Tg-felg-IP1136-Ab-2 | Anti-Feline MAL monoclonal antibody | Feline |
| GM-Tg-cang-IP1136-Ab-1/ GM-Tg-cang-IP1136-Ab-2 | Anti-Canine MAL monoclonal antibody | Canine |
| GM-Tg-bovg-IP1136-Ab-1/ GM-Tg-bovg-IP1136-Ab-2 | Anti-Bovine MAL monoclonal antibody | Bovine |
| GM-Tg-equg-IP1136-Ab-1/ GM-Tg-equg-IP1136-Ab-2 | Anti-Equine MAL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1136-Ab-1/ GM-Tg-hg-IP1136-Ab-2; GM-Tg-rg-IP1136-Ab-1/ GM-Tg-rg-IP1136-Ab-2; GM-Tg-mg-IP1136-Ab-1/ GM-Tg-mg-IP1136-Ab-2; GM-Tg-cynog-IP1136-Ab-1/ GM-Tg-cynog-IP1136-Ab-2; GM-Tg-felg-IP1136-Ab-1/ GM-Tg-felg-IP1136-Ab-2; GM-Tg-cang-IP1136-Ab-1/ GM-Tg-cang-IP1136-Ab-2; GM-Tg-bovg-IP1136-Ab-1/ GM-Tg-bovg-IP1136-Ab-2; GM-Tg-equg-IP1136-Ab-1/ GM-Tg-equg-IP1136-Ab-2 |
| Products Name | Anti-MAL monoclonal antibody |
| Format | mab |
| Target Name | MAL |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MAL monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1136-Ag-1 | Recombinant multi-species MAL/ MVP17/ VIP17 protein |
| ORF Viral Vector | pGMLP002779 | human MAL Lentivirus plasmid |
| ORF Viral Vector | vGMLP002779 | human MAL Lentivirus particle |
| ORF Viral Vector | pGMLPm000956 | mouse Mal Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000956 | mouse Mal Lentivirus particle |
Target information
| Target ID | GM-IP1136 |
| Target Name | MAL |
| Gene ID | 4118,17153,25263,703532,403933,101085795,510077 |
| Gene Symbol and Synonyms | MAL,MALGENE,Mpv17,MVP17,VIP17 |
| Uniprot Accession | P21145,Q64349,Q28296,Q3ZBY0 |
| Uniprot Entry Name | MAL_HUMAN,MAL_RAT,MAL_CANLF,MAL_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000172005 |
| Target Classification | N/A |
The target: MAL, gene name: MAL, also named as MVP17, VIP17. The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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