- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-MANEA monoclonal antibody
Pre-made anti-MANEA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MANEA/MANEA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1146-Ab-1/ GM-Tg-hg-IP1146-Ab-2 | Anti-Human MANEA monoclonal antibody | Human |
| GM-Tg-rg-IP1146-Ab-1/ GM-Tg-rg-IP1146-Ab-2 | Anti-Rat MANEA monoclonal antibody | Rat |
| GM-Tg-mg-IP1146-Ab-1/ GM-Tg-mg-IP1146-Ab-2 | Anti-Mouse MANEA monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1146-Ab-1/ GM-Tg-cynog-IP1146-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MANEA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1146-Ab-1/ GM-Tg-felg-IP1146-Ab-2 | Anti-Feline MANEA monoclonal antibody | Feline |
| GM-Tg-cang-IP1146-Ab-1/ GM-Tg-cang-IP1146-Ab-2 | Anti-Canine MANEA monoclonal antibody | Canine |
| GM-Tg-bovg-IP1146-Ab-1/ GM-Tg-bovg-IP1146-Ab-2 | Anti-Bovine MANEA monoclonal antibody | Bovine |
| GM-Tg-equg-IP1146-Ab-1/ GM-Tg-equg-IP1146-Ab-2 | Anti-Equine MANEA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1146-Ab-1/ GM-Tg-hg-IP1146-Ab-2; GM-Tg-rg-IP1146-Ab-1/ GM-Tg-rg-IP1146-Ab-2; GM-Tg-mg-IP1146-Ab-1/ GM-Tg-mg-IP1146-Ab-2; GM-Tg-cynog-IP1146-Ab-1/ GM-Tg-cynog-IP1146-Ab-2; GM-Tg-felg-IP1146-Ab-1/ GM-Tg-felg-IP1146-Ab-2; GM-Tg-cang-IP1146-Ab-1/ GM-Tg-cang-IP1146-Ab-2; GM-Tg-bovg-IP1146-Ab-1/ GM-Tg-bovg-IP1146-Ab-2; GM-Tg-equg-IP1146-Ab-1/ GM-Tg-equg-IP1146-Ab-2 |
| Products Name | Anti-MANEA monoclonal antibody |
| Format | mab |
| Target Name | MANEA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MANEA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1146-Ag-1 | Recombinant multi-species MANEA/ ENDO/ hEndo protein |
| ORF Viral Vector | vGMLP001686 | human MANEA Lentivirus particle |
| ORF Viral Vector | pGMLP001686 | human MANEA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002664 | mouse Manea Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002664 | mouse Manea Lentivirus particle |
Target information
| Target ID | GM-IP1146 |
| Target Name | MANEA |
| Gene ID | 79694,242362,140808,708164,481925,101101567,512853,100065922 |
| Gene Symbol and Synonyms | 4932703L02Rik,ENDO,Enman,hEndo,MANEA |
| Uniprot Accession | Q5SRI9,Q5GF25 |
| Uniprot Entry Name | MANEA_HUMAN,MANEA_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000172469 |
| Target Classification | N/A |
The target: MANEA, gene name: MANEA, also named as ENDO, hEndo. N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
