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Anti-RAD51B monoclonal antibody
Pre-made anti-RAD51B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RAD51B/RAD51B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1468-Ab-1/ GM-Tg-hg-IP1468-Ab-2 | Anti-Human RAD51B monoclonal antibody | Human |
| GM-Tg-rg-IP1468-Ab-1/ GM-Tg-rg-IP1468-Ab-2 | Anti-Rat RAD51B monoclonal antibody | Rat |
| GM-Tg-mg-IP1468-Ab-1/ GM-Tg-mg-IP1468-Ab-2 | Anti-Mouse RAD51B monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1468-Ab-1/ GM-Tg-cynog-IP1468-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RAD51B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1468-Ab-1/ GM-Tg-felg-IP1468-Ab-2 | Anti-Feline RAD51B monoclonal antibody | Feline |
| GM-Tg-cang-IP1468-Ab-1/ GM-Tg-cang-IP1468-Ab-2 | Anti-Canine RAD51B monoclonal antibody | Canine |
| GM-Tg-bovg-IP1468-Ab-1/ GM-Tg-bovg-IP1468-Ab-2 | Anti-Bovine RAD51B monoclonal antibody | Bovine |
| GM-Tg-equg-IP1468-Ab-1/ GM-Tg-equg-IP1468-Ab-2 | Anti-Equine RAD51B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1468-Ab-1/ GM-Tg-hg-IP1468-Ab-2; GM-Tg-rg-IP1468-Ab-1/ GM-Tg-rg-IP1468-Ab-2; GM-Tg-mg-IP1468-Ab-1/ GM-Tg-mg-IP1468-Ab-2; GM-Tg-cynog-IP1468-Ab-1/ GM-Tg-cynog-IP1468-Ab-2; GM-Tg-felg-IP1468-Ab-1/ GM-Tg-felg-IP1468-Ab-2; GM-Tg-cang-IP1468-Ab-1/ GM-Tg-cang-IP1468-Ab-2; GM-Tg-bovg-IP1468-Ab-1/ GM-Tg-bovg-IP1468-Ab-2; GM-Tg-equg-IP1468-Ab-1/ GM-Tg-equg-IP1468-Ab-2 |
| Products Name | Anti-RAD51B monoclonal antibody |
| Format | mab |
| Target Name | RAD51B |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RAD51B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1468-Ag-1 | Recombinant multi-species RA51B/ RAD51B/ R51H2 protein |
| ORF Viral Vector | vGMLP001722 | human RAD51B Lentivirus particle |
| ORF Viral Vector | pGMLP001722 | human RAD51B Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001789 | mouse Rad51b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001789 | mouse Rad51b Lentivirus particle |
Target information
| Target ID | GM-IP1468 |
| Target Name | RAD51B |
| Gene ID | 5890,19363,500679,711358,490746,101097071,617007,100053023 |
| Gene Symbol and Synonyms | mREC2,R51H2,RAD51B,RAD51L1,REC2,RGD1560681 |
| Uniprot Accession | O15315 |
| Uniprot Entry Name | RA51B_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000182185 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: RAD51B, gene name: RAD51B, also named as R51H2, RAD51L1, REC2. The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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