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Anti-RGR monoclonal antibody
Pre-made anti-RGR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RGR/RGR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1486-Ab-1/ GM-Tg-hg-IP1486-Ab-2 | Anti-Human RGR monoclonal antibody | Human |
| GM-Tg-rg-IP1486-Ab-1/ GM-Tg-rg-IP1486-Ab-2 | Anti-Rat RGR monoclonal antibody | Rat |
| GM-Tg-mg-IP1486-Ab-1/ GM-Tg-mg-IP1486-Ab-2 | Anti-Mouse RGR monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1486-Ab-1/ GM-Tg-cynog-IP1486-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RGR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1486-Ab-1/ GM-Tg-felg-IP1486-Ab-2 | Anti-Feline RGR monoclonal antibody | Feline |
| GM-Tg-cang-IP1486-Ab-1/ GM-Tg-cang-IP1486-Ab-2 | Anti-Canine RGR monoclonal antibody | Canine |
| GM-Tg-bovg-IP1486-Ab-1/ GM-Tg-bovg-IP1486-Ab-2 | Anti-Bovine RGR monoclonal antibody | Bovine |
| GM-Tg-equg-IP1486-Ab-1/ GM-Tg-equg-IP1486-Ab-2 | Anti-Equine RGR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1486-Ab-1/ GM-Tg-hg-IP1486-Ab-2; GM-Tg-rg-IP1486-Ab-1/ GM-Tg-rg-IP1486-Ab-2; GM-Tg-mg-IP1486-Ab-1/ GM-Tg-mg-IP1486-Ab-2; GM-Tg-cynog-IP1486-Ab-1/ GM-Tg-cynog-IP1486-Ab-2; GM-Tg-felg-IP1486-Ab-1/ GM-Tg-felg-IP1486-Ab-2; GM-Tg-cang-IP1486-Ab-1/ GM-Tg-cang-IP1486-Ab-2; GM-Tg-bovg-IP1486-Ab-1/ GM-Tg-bovg-IP1486-Ab-2; GM-Tg-equg-IP1486-Ab-1/ GM-Tg-equg-IP1486-Ab-2 |
| Products Name | Anti-RGR monoclonal antibody |
| Format | mab |
| Target Name | RGR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RGR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1486-Ag-1 | Recombinant multi-species RGR/ RP44 protein |
| ORF Viral Vector | vGMLP004932 | human Rgr Lentivirus particle |
| ORF Viral Vector | pGMLP004932 | human Rgr Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000436 | mouse Rgr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000436 | mouse Rgr Lentivirus particle |
Target information
| Target ID | GM-IP1486 |
| Target Name | RGR |
| Gene ID | 5995,57811,306307,698258,489072,101083036,280911,100065091 |
| Gene Symbol and Synonyms | RGR,RP44 |
| Uniprot Accession | P47804,P47803 |
| Uniprot Entry Name | RGR_HUMAN,RGR_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000148604 |
| Target Classification | N/A |
The target: RGR, gene name: RGR, also named as RP44. This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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