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Anti-SPACA1 monoclonal antibody
Pre-made anti-SPACA1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SPACA1/SPACA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1790-Ab-1/ GM-Tg-hg-IP1790-Ab-2 | Anti-Human SPACA1 monoclonal antibody | Human |
| GM-Tg-rg-IP1790-Ab-1/ GM-Tg-rg-IP1790-Ab-2 | Anti-Rat SPACA1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1790-Ab-1/ GM-Tg-mg-IP1790-Ab-2 | Anti-Mouse SPACA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1790-Ab-1/ GM-Tg-cynog-IP1790-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPACA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1790-Ab-1/ GM-Tg-felg-IP1790-Ab-2 | Anti-Feline SPACA1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1790-Ab-1/ GM-Tg-cang-IP1790-Ab-2 | Anti-Canine SPACA1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1790-Ab-1/ GM-Tg-bovg-IP1790-Ab-2 | Anti-Bovine SPACA1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1790-Ab-1/ GM-Tg-equg-IP1790-Ab-2 | Anti-Equine SPACA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1790-Ab-1/ GM-Tg-hg-IP1790-Ab-2; GM-Tg-rg-IP1790-Ab-1/ GM-Tg-rg-IP1790-Ab-2; GM-Tg-mg-IP1790-Ab-1/ GM-Tg-mg-IP1790-Ab-2; GM-Tg-cynog-IP1790-Ab-1/ GM-Tg-cynog-IP1790-Ab-2; GM-Tg-felg-IP1790-Ab-1/ GM-Tg-felg-IP1790-Ab-2; GM-Tg-cang-IP1790-Ab-1/ GM-Tg-cang-IP1790-Ab-2; GM-Tg-bovg-IP1790-Ab-1/ GM-Tg-bovg-IP1790-Ab-2; GM-Tg-equg-IP1790-Ab-1/ GM-Tg-equg-IP1790-Ab-2 |
| Products Name | Anti-SPACA1 monoclonal antibody |
| Format | mab |
| Target Name | SPACA1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SPACA1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1790-Ag-1 | Recombinant multi-species SACA1/ SPACA1/ SAMP32 protein |
Target information
| Target ID | GM-IP1790 |
| Target Name | SPACA1 |
| Gene ID | 81833,67652,500432,699611,611635,101091941,614884,100070753 |
| Gene Symbol and Synonyms | 1700124L11Rik,4930540L03Rik,RGD1560284,SAMP32,SPACA1 |
| Uniprot Accession | Q9HBV2,Q2YDG7 |
| Uniprot Entry Name | SACA1_HUMAN,SACA1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000118434 |
| Target Classification | N/A |
The target: SPACA1, gene name: SPACA1, also named as SAMP32. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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