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Anti-™EM43 monoclonal antibody
Pre-made anti-™EM43 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ™EM43/™EM43 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2104-Ab-1/ GM-Tg-hg-IP2104-Ab-2 | Anti-Human ™EM43 monoclonal antibody | Human |
| GM-Tg-rg-IP2104-Ab-1/ GM-Tg-rg-IP2104-Ab-2 | Anti-Rat ™EM43 monoclonal antibody | Rat |
| GM-Tg-mg-IP2104-Ab-1/ GM-Tg-mg-IP2104-Ab-2 | Anti-Mouse ™EM43 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2104-Ab-1/ GM-Tg-cynog-IP2104-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ™EM43 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2104-Ab-1/ GM-Tg-felg-IP2104-Ab-2 | Anti-Feline ™EM43 monoclonal antibody | Feline |
| GM-Tg-cang-IP2104-Ab-1/ GM-Tg-cang-IP2104-Ab-2 | Anti-Canine ™EM43 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2104-Ab-1/ GM-Tg-bovg-IP2104-Ab-2 | Anti-Bovine ™EM43 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2104-Ab-1/ GM-Tg-equg-IP2104-Ab-2 | Anti-Equine ™EM43 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2104-Ab-1/ GM-Tg-hg-IP2104-Ab-2; GM-Tg-rg-IP2104-Ab-1/ GM-Tg-rg-IP2104-Ab-2; GM-Tg-mg-IP2104-Ab-1/ GM-Tg-mg-IP2104-Ab-2; GM-Tg-cynog-IP2104-Ab-1/ GM-Tg-cynog-IP2104-Ab-2; GM-Tg-felg-IP2104-Ab-1/ GM-Tg-felg-IP2104-Ab-2; GM-Tg-cang-IP2104-Ab-1/ GM-Tg-cang-IP2104-Ab-2; GM-Tg-bovg-IP2104-Ab-1/ GM-Tg-bovg-IP2104-Ab-2; GM-Tg-equg-IP2104-Ab-1/ GM-Tg-equg-IP2104-Ab-2 |
| Products Name | Anti-™EM43 monoclonal antibody |
| Format | mab |
| Target Name | ™EM43 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-™EM43 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2104-Ag-1 | Recombinant multi-species ™M43/ ™EM43/ ARVC5 protein |
| ORF Viral Vector | pGMLP004256 | human ™EM43 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004256 | human ™EM43 Lentivirus particle |
| ORF Viral Vector | pGMLPm005104 | mouse Tmem43 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005104 | mouse Tmem43 Lentivirus particle |
Target information
| Target ID | GM-IP2104 |
| Target Name | ™EM43 |
| Gene ID | 79188,74122,362401,700689,484637,101080877,404066,100055748 |
| Gene Symbol and Synonyms | 1200015A22Rik,ARVC5,ARVD5,AUNA3,EDMD7,EDMD7; AUNA2,LUMA,™EM43 |
| Uniprot Accession | Q9BTV4,Q5XIP9 |
| Uniprot Entry Name | ™M43_HUMAN,™M43_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000170876 |
| Target Classification | N/A |
The target: ™EM43, gene name: ™EM43, also named as ARVC5, ARVD5, EDMD7, LUMA. This gene belongs to the ™EM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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