Anti-TPM1 monoclonal antibody

Pre-made anti-TPM1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to TPM1/TPM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2167-Ab-1/ GM-Tg-hg-IP2167-Ab-2Anti-Human TPM1 monoclonal antibodyHuman
GM-Tg-rg-IP2167-Ab-1/ GM-Tg-rg-IP2167-Ab-2Anti-Rat TPM1 monoclonal antibodyRat
GM-Tg-mg-IP2167-Ab-1/ GM-Tg-mg-IP2167-Ab-2Anti-Mouse TPM1 monoclonal antibodyMouse
GM-Tg-cynog-IP2167-Ab-1/ GM-Tg-cynog-IP2167-Ab-2Anti-Cynomolgus/ Rhesus macaque TPM1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2167-Ab-1/ GM-Tg-felg-IP2167-Ab-2Anti-Feline TPM1 monoclonal antibodyFeline
GM-Tg-cang-IP2167-Ab-1/ GM-Tg-cang-IP2167-Ab-2Anti-Canine TPM1 monoclonal antibodyCanine
GM-Tg-bovg-IP2167-Ab-1/ GM-Tg-bovg-IP2167-Ab-2Anti-Bovine TPM1 monoclonal antibodyBovine
GM-Tg-equg-IP2167-Ab-1/ GM-Tg-equg-IP2167-Ab-2Anti-Equine TPM1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2167-Ab-1/ GM-Tg-hg-IP2167-Ab-2; GM-Tg-rg-IP2167-Ab-1/ GM-Tg-rg-IP2167-Ab-2;
GM-Tg-mg-IP2167-Ab-1/ GM-Tg-mg-IP2167-Ab-2; GM-Tg-cynog-IP2167-Ab-1/ GM-Tg-cynog-IP2167-Ab-2;
GM-Tg-felg-IP2167-Ab-1/ GM-Tg-felg-IP2167-Ab-2; GM-Tg-cang-IP2167-Ab-1/ GM-Tg-cang-IP2167-Ab-2;
GM-Tg-bovg-IP2167-Ab-1/ GM-Tg-bovg-IP2167-Ab-2; GM-Tg-equg-IP2167-Ab-1/ GM-Tg-equg-IP2167-Ab-2
Products NameAnti-TPM1 monoclonal antibody
Formatmab
Target NameTPM1
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-TPM1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2167-Ag-1Recombinant multi-species TPM1/ C15orf13/ CMD1Y protein
    ORF Viral VectorpGMLP003971human TPM1 Lentivirus plasmid
    ORF Viral VectorvGMLP003971human TPM1 Lentivirus particle
    ORF Viral VectorpGMLPm000852mouse Tpm1 Lentivirus plasmid
    ORF Viral VectorpGMLPm000853mouse Tpm1 Lentivirus plasmid
    ORF Viral VectorvGMLPm000852mouse Tpm1 Lentivirus particle
    ORF Viral VectorvGMLPm000853mouse Tpm1 Lentivirus particle


    Target information

    Target IDGM-IP2167
    Target NameTPM1
    Gene ID7168,22003,24851,705236,478332,101091450,281544,100067330
    Gene Symbol and Synonymsalpha-™,C15orf13,CMD1Y,CMH3,HEL-S-265,H™-alpha,LVNC9,™2,Tm3,Tma2,Tmpa,™SA,Tpm-1,TPM1,TPM1kappa
    Uniprot AccessionP09493,P04692,Q5KR49
    Uniprot Entry NameTPM1_HUMAN,TPM1_RAT,TPM1_BOVIN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseObstructive sleep apnea (adult) (pediatric)
    Gene EnsemblENSG00000140416
    Target ClassificationN/A

    The target: TPM1, gene name: TPM1, also named as C15orf13, CMD1Y, CMH3, HEL-S-265, H™-alpha, LVNC9, ™SA. This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.