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Anti-TSC2 monoclonal antibody
Pre-made anti-TSC2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TSC2/TSC2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2180-Ab-1/ GM-Tg-hg-IP2180-Ab-2 | Anti-Human TSC2 monoclonal antibody | Human |
| GM-Tg-rg-IP2180-Ab-1/ GM-Tg-rg-IP2180-Ab-2 | Anti-Rat TSC2 monoclonal antibody | Rat |
| GM-Tg-mg-IP2180-Ab-1/ GM-Tg-mg-IP2180-Ab-2 | Anti-Mouse TSC2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2180-Ab-1/ GM-Tg-cynog-IP2180-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TSC2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2180-Ab-1/ GM-Tg-felg-IP2180-Ab-2 | Anti-Feline TSC2 monoclonal antibody | Feline |
| GM-Tg-cang-IP2180-Ab-1/ GM-Tg-cang-IP2180-Ab-2 | Anti-Canine TSC2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2180-Ab-1/ GM-Tg-bovg-IP2180-Ab-2 | Anti-Bovine TSC2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2180-Ab-1/ GM-Tg-equg-IP2180-Ab-2 | Anti-Equine TSC2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2180-Ab-1/ GM-Tg-hg-IP2180-Ab-2; GM-Tg-rg-IP2180-Ab-1/ GM-Tg-rg-IP2180-Ab-2; GM-Tg-mg-IP2180-Ab-1/ GM-Tg-mg-IP2180-Ab-2; GM-Tg-cynog-IP2180-Ab-1/ GM-Tg-cynog-IP2180-Ab-2; GM-Tg-felg-IP2180-Ab-1/ GM-Tg-felg-IP2180-Ab-2; GM-Tg-cang-IP2180-Ab-1/ GM-Tg-cang-IP2180-Ab-2; GM-Tg-bovg-IP2180-Ab-1/ GM-Tg-bovg-IP2180-Ab-2; GM-Tg-equg-IP2180-Ab-1/ GM-Tg-equg-IP2180-Ab-2 |
| Products Name | Anti-TSC2 monoclonal antibody |
| Format | mab |
| Target Name | TSC2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TSC2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2180-Ag-1 | Recombinant multi-species TSC2/ LAM/ PPP1R160 protein |
Target information
| Target ID | GM-IP2180 |
| Target Name | TSC2 |
| Gene ID | 7249,22084,24855,694965,479883,101082969,504985,100065679 |
| Gene Symbol and Synonyms | LAM,Nafld,PPP1R160,Rc,Tcs2,TSC2,TSC4 |
| Uniprot Accession | P49815,P49816 |
| Uniprot Entry Name | TSC2_HUMAN,TSC2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000103197 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: TSC2, gene name: TSC2, also named as LAM, PPP1R160, TSC4. This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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