Anti-XBP1 monoclonal antibody
Pre-made anti-XBP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-IP2282-Ab-1/ GM-Tg-hg-IP2282-Ab-2 | Anti-Human XBP1 monoclonal antibody | Human |
GM-Tg-rg-IP2282-Ab-1/ GM-Tg-rg-IP2282-Ab-2 | Anti-Rat XBP1 monoclonal antibody | Rat |
GM-Tg-mg-IP2282-Ab-1/ GM-Tg-mg-IP2282-Ab-2 | Anti-Mouse XBP1 monoclonal antibody | Mouse |
GM-Tg-cynog-IP2282-Ab-1/ GM-Tg-cynog-IP2282-Ab-2 | Anti-Cynomolgus/ Rhesus macaque XBP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-IP2282-Ab-1/ GM-Tg-felg-IP2282-Ab-2 | Anti-Feline XBP1 monoclonal antibody | Feline |
GM-Tg-cang-IP2282-Ab-1/ GM-Tg-cang-IP2282-Ab-2 | Anti-Canine XBP1 monoclonal antibody | Canine |
GM-Tg-bovg-IP2282-Ab-1/ GM-Tg-bovg-IP2282-Ab-2 | Anti-Bovine XBP1 monoclonal antibody | Bovine |
GM-Tg-equg-IP2282-Ab-1/ GM-Tg-equg-IP2282-Ab-2 | Anti-Equine XBP1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-IP2282-Ab-1/ GM-Tg-hg-IP2282-Ab-2; GM-Tg-rg-IP2282-Ab-1/ GM-Tg-rg-IP2282-Ab-2; GM-Tg-mg-IP2282-Ab-1/ GM-Tg-mg-IP2282-Ab-2; GM-Tg-cynog-IP2282-Ab-1/ GM-Tg-cynog-IP2282-Ab-2; GM-Tg-felg-IP2282-Ab-1/ GM-Tg-felg-IP2282-Ab-2; GM-Tg-cang-IP2282-Ab-1/ GM-Tg-cang-IP2282-Ab-2; GM-Tg-bovg-IP2282-Ab-1/ GM-Tg-bovg-IP2282-Ab-2; GM-Tg-equg-IP2282-Ab-1/ GM-Tg-equg-IP2282-Ab-2 |
Products Name | Anti-XBP1 monoclonal antibody |
Format | mab |
Target Name | XBP1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-XBP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-IP2282-Ag-1 | Recombinant multi-species XBP1/ TREB-5/ TREB5 protein |
ORF Viral Vector | pGMAAV000330 | Norway rat Xbp1 AAV plasmid |
ORF Viral Vector | pGMLPm002838 | mouse Xbp1 Lentivirus plasmid |
ORF Viral Vector | vGMAAV000330 | Norway rat Xbp1 AAV particle |
ORF Viral Vector | vGMLPm002838 | mouse Xbp1 Lentivirus particle |
Target information
Target ID | GM-IP2282 |
Target Name | XBP1 |
Gene ID | 7494,22433,289754,713863,477532,101092150,541236,100059209 |
Gene Symbol and Synonyms | D11Ertd39e,HTF,TREB-5,TREB5,XBP-1,XBP1,XBP1P1,XBP2,XBPP1 |
Uniprot Accession | P17861,Q9R1S4,Q3SZZ2 |
Uniprot Entry Name | XBP1_HUMAN,XBP1_RAT,XBP1_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | |
Disease | Breast Cancer |
Gene Ensembl | ENSG00000100219 |
Target Classification | Pathway |
The target: XBP1, gene name: XBP1, also named as TREB-5, TREB5, XBP-1, XBP2. This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.