- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-ALOXE3 monoclonal antibody
Pre-made anti-ALOXE3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ALOXE3/ALOXE3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2336-Ab-1/ GM-Tg-hg-IP2336-Ab-2 | Anti-Human ALOXE3 monoclonal antibody | Human |
| GM-Tg-rg-IP2336-Ab-1/ GM-Tg-rg-IP2336-Ab-2 | Anti-Rat ALOXE3 monoclonal antibody | Rat |
| GM-Tg-mg-IP2336-Ab-1/ GM-Tg-mg-IP2336-Ab-2 | Anti-Mouse ALOXE3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2336-Ab-1/ GM-Tg-cynog-IP2336-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ALOXE3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2336-Ab-1/ GM-Tg-felg-IP2336-Ab-2 | Anti-Feline ALOXE3 monoclonal antibody | Feline |
| GM-Tg-cang-IP2336-Ab-1/ GM-Tg-cang-IP2336-Ab-2 | Anti-Canine ALOXE3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2336-Ab-1/ GM-Tg-bovg-IP2336-Ab-2 | Anti-Bovine ALOXE3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2336-Ab-1/ GM-Tg-equg-IP2336-Ab-2 | Anti-Equine ALOXE3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2336-Ab-1/ GM-Tg-hg-IP2336-Ab-2; GM-Tg-rg-IP2336-Ab-1/ GM-Tg-rg-IP2336-Ab-2; GM-Tg-mg-IP2336-Ab-1/ GM-Tg-mg-IP2336-Ab-2; GM-Tg-cynog-IP2336-Ab-1/ GM-Tg-cynog-IP2336-Ab-2; GM-Tg-felg-IP2336-Ab-1/ GM-Tg-felg-IP2336-Ab-2; GM-Tg-cang-IP2336-Ab-1/ GM-Tg-cang-IP2336-Ab-2; GM-Tg-bovg-IP2336-Ab-1/ GM-Tg-bovg-IP2336-Ab-2; GM-Tg-equg-IP2336-Ab-1/ GM-Tg-equg-IP2336-Ab-2 |
| Products Name | Anti-ALOXE3 monoclonal antibody |
| Format | mab |
| Target Name | ALOXE3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ALOXE3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2336-Ag-1 | Recombinant multi-species LOXE3/ ALOXE3/ ARCI3 protein |
| ORF Viral Vector | pGMLPm004335 | mouse Aloxe3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004335 | mouse Aloxe3 Lentivirus particle |
Target information
| Target ID | GM-IP2336 |
| Target Name | ALOXE3 |
| Gene ID | 59344,23801,287424,716840,489487,101101515,517001,100062351 |
| Gene Symbol and Synonyms | ALOXE3,ARCI3,E-LOX,e-LOX-3,eLOX-3,eLOX3,LI5 |
| Uniprot Accession | Q9BYJ1,D3ZKX9 |
| Uniprot Entry Name | LOXE3_HUMAN,LOXE3_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000179148 |
| Target Classification | N/A |
The target: ALOXE3, gene name: ALOXE3, also named as ARCI3, E-LOX, eLOX-3, eLOX3. This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
