- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-DDB2 monoclonal antibody
Pre-made anti-DDB2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DDB2/DDB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2450-Ab-1/ GM-Tg-hg-IP2450-Ab-2 | Anti-Human DDB2 monoclonal antibody | Human |
| GM-Tg-rg-IP2450-Ab-1/ GM-Tg-rg-IP2450-Ab-2 | Anti-Rat DDB2 monoclonal antibody | Rat |
| GM-Tg-mg-IP2450-Ab-1/ GM-Tg-mg-IP2450-Ab-2 | Anti-Mouse DDB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2450-Ab-1/ GM-Tg-cynog-IP2450-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DDB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2450-Ab-1/ GM-Tg-felg-IP2450-Ab-2 | Anti-Feline DDB2 monoclonal antibody | Feline |
| GM-Tg-cang-IP2450-Ab-1/ GM-Tg-cang-IP2450-Ab-2 | Anti-Canine DDB2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2450-Ab-1/ GM-Tg-bovg-IP2450-Ab-2 | Anti-Bovine DDB2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2450-Ab-1/ GM-Tg-equg-IP2450-Ab-2 | Anti-Equine DDB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2450-Ab-1/ GM-Tg-hg-IP2450-Ab-2; GM-Tg-rg-IP2450-Ab-1/ GM-Tg-rg-IP2450-Ab-2; GM-Tg-mg-IP2450-Ab-1/ GM-Tg-mg-IP2450-Ab-2; GM-Tg-cynog-IP2450-Ab-1/ GM-Tg-cynog-IP2450-Ab-2; GM-Tg-felg-IP2450-Ab-1/ GM-Tg-felg-IP2450-Ab-2; GM-Tg-cang-IP2450-Ab-1/ GM-Tg-cang-IP2450-Ab-2; GM-Tg-bovg-IP2450-Ab-1/ GM-Tg-bovg-IP2450-Ab-2; GM-Tg-equg-IP2450-Ab-1/ GM-Tg-equg-IP2450-Ab-2 |
| Products Name | Anti-DDB2 monoclonal antibody |
| Format | mab |
| Target Name | DDB2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DDB2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2450-Ag-1 | Recombinant multi-species DDB2/ DDBB/ UV-DDB2 protein |
| ORF Viral Vector | vGMLP003996 | human DDB2 Lentivirus particle |
| ORF Viral Vector | pGMLP003996 | human DDB2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005245 | mouse Ddb2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005245 | mouse Ddb2 Lentivirus particle |
Target information
| Target ID | GM-IP2450 |
| Target Name | DDB2 |
| Gene ID | 1643,107986,100362121,483626,101092211,519357,100051180 |
| Gene Symbol and Synonyms | 2610043A19Rik,DDB2,DDBB,UV-DDB2,XPE |
| Uniprot Accession | Q92466,Q0VBY8 |
| Uniprot Entry Name | DDB2_HUMAN,DDB2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000134574 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DDB2, gene name: DDB2, also named as DDBB, UV-DDB2, XPE. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
