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Anti-PPM1F monoclonal antibody
Pre-made anti-PPM1F monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PPM1F/PPM1F products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2664-Ab-1/ GM-Tg-hg-IP2664-Ab-2 | Anti-Human PPM1F monoclonal antibody | Human |
| GM-Tg-rg-IP2664-Ab-1/ GM-Tg-rg-IP2664-Ab-2 | Anti-Rat PPM1F monoclonal antibody | Rat |
| GM-Tg-mg-IP2664-Ab-1/ GM-Tg-mg-IP2664-Ab-2 | Anti-Mouse PPM1F monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2664-Ab-1/ GM-Tg-cynog-IP2664-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPM1F monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2664-Ab-1/ GM-Tg-felg-IP2664-Ab-2 | Anti-Feline PPM1F monoclonal antibody | Feline |
| GM-Tg-cang-IP2664-Ab-1/ GM-Tg-cang-IP2664-Ab-2 | Anti-Canine PPM1F monoclonal antibody | Canine |
| GM-Tg-bovg-IP2664-Ab-1/ GM-Tg-bovg-IP2664-Ab-2 | Anti-Bovine PPM1F monoclonal antibody | Bovine |
| GM-Tg-equg-IP2664-Ab-1/ GM-Tg-equg-IP2664-Ab-2 | Anti-Equine PPM1F monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2664-Ab-1/ GM-Tg-hg-IP2664-Ab-2; GM-Tg-rg-IP2664-Ab-1/ GM-Tg-rg-IP2664-Ab-2; GM-Tg-mg-IP2664-Ab-1/ GM-Tg-mg-IP2664-Ab-2; GM-Tg-cynog-IP2664-Ab-1/ GM-Tg-cynog-IP2664-Ab-2; GM-Tg-felg-IP2664-Ab-1/ GM-Tg-felg-IP2664-Ab-2; GM-Tg-cang-IP2664-Ab-1/ GM-Tg-cang-IP2664-Ab-2; GM-Tg-bovg-IP2664-Ab-1/ GM-Tg-bovg-IP2664-Ab-2; GM-Tg-equg-IP2664-Ab-1/ GM-Tg-equg-IP2664-Ab-2 |
| Products Name | Anti-PPM1F monoclonal antibody |
| Format | mab |
| Target Name | PPM1F |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PPM1F monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2664-Ag-1 | Recombinant multi-species PPM1F/ CAMKP/ CaMKPase protein |
| ORF Viral Vector | pGMLPm003840 | mouse Ppm1f Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003840 | mouse Ppm1f Lentivirus particle |
Target information
| Target ID | GM-IP2664 |
| Target Name | PPM1F |
| Gene ID | 9647,68606,287931,698441,486448,101087876,618210,100057884 |
| Gene Symbol and Synonyms | 1110021B16Rik,4933427B07Rik,CAMKP,CaMKPase,FEM-2,hFEM-2,mKIAA0015,POPX2,PPM1F |
| Uniprot Accession | P49593,Q9WVR7 |
| Uniprot Entry Name | PPM1F_HUMAN,PPM1F_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000100034 |
| Target Classification | N/A |
The target: PPM1F, gene name: PPM1F, also named as CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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