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Anti-RAD51C monoclonal antibody
Pre-made anti-RAD51C monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RAD51C/RAD51C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2689-Ab-1/ GM-Tg-hg-IP2689-Ab-2 | Anti-Human RAD51C monoclonal antibody | Human |
| GM-Tg-rg-IP2689-Ab-1/ GM-Tg-rg-IP2689-Ab-2 | Anti-Rat RAD51C monoclonal antibody | Rat |
| GM-Tg-mg-IP2689-Ab-1/ GM-Tg-mg-IP2689-Ab-2 | Anti-Mouse RAD51C monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2689-Ab-1/ GM-Tg-cynog-IP2689-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RAD51C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2689-Ab-1/ GM-Tg-felg-IP2689-Ab-2 | Anti-Feline RAD51C monoclonal antibody | Feline |
| GM-Tg-cang-IP2689-Ab-1/ GM-Tg-cang-IP2689-Ab-2 | Anti-Canine RAD51C monoclonal antibody | Canine |
| GM-Tg-bovg-IP2689-Ab-1/ GM-Tg-bovg-IP2689-Ab-2 | Anti-Bovine RAD51C monoclonal antibody | Bovine |
| GM-Tg-equg-IP2689-Ab-1/ GM-Tg-equg-IP2689-Ab-2 | Anti-Equine RAD51C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2689-Ab-1/ GM-Tg-hg-IP2689-Ab-2; GM-Tg-rg-IP2689-Ab-1/ GM-Tg-rg-IP2689-Ab-2; GM-Tg-mg-IP2689-Ab-1/ GM-Tg-mg-IP2689-Ab-2; GM-Tg-cynog-IP2689-Ab-1/ GM-Tg-cynog-IP2689-Ab-2; GM-Tg-felg-IP2689-Ab-1/ GM-Tg-felg-IP2689-Ab-2; GM-Tg-cang-IP2689-Ab-1/ GM-Tg-cang-IP2689-Ab-2; GM-Tg-bovg-IP2689-Ab-1/ GM-Tg-bovg-IP2689-Ab-2; GM-Tg-equg-IP2689-Ab-1/ GM-Tg-equg-IP2689-Ab-2 |
| Products Name | Anti-RAD51C monoclonal antibody |
| Format | mab |
| Target Name | RAD51C |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RAD51C monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2689-Ag-1 | Recombinant multi-species RA51C/ RAD51C/ BROVCA3 protein |
| ORF Viral Vector | pGMLP003608 | human RAD51C Lentivirus plasmid |
| ORF Viral Vector | vGMLP003608 | human RAD51C Lentivirus particle |
| ORF Viral Vector | pGMLPm005166 | mouse Rad51c Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005166 | mouse Rad51c Lentivirus particle |
Target information
| Target ID | GM-IP2689 |
| Target Name | RAD51C |
| Gene ID | 5889,114714,497976,714828,480573,101096020,540886,100070966 |
| Gene Symbol and Synonyms | BROVCA3,FANCO,R51H3,RAD51C,RAD51L2,RGD1563765 |
| Uniprot Accession | O43502 |
| Uniprot Entry Name | RA51C_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000108384 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: RAD51C, gene name: RAD51C, also named as BROVCA3, FANCO, R51H3, RAD51L2. This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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