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Anti-RFLNB monoclonal antibody
Pre-made anti-RFLNB monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RFLNB/RFLNB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2697-Ab-1/ GM-Tg-hg-IP2697-Ab-2 | Anti-Human RFLNB monoclonal antibody | Human |
| GM-Tg-rg-IP2697-Ab-1/ GM-Tg-rg-IP2697-Ab-2 | Anti-Rat RFLNB monoclonal antibody | Rat |
| GM-Tg-mg-IP2697-Ab-1/ GM-Tg-mg-IP2697-Ab-2 | Anti-Mouse RFLNB monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2697-Ab-1/ GM-Tg-cynog-IP2697-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RFLNB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2697-Ab-1/ GM-Tg-felg-IP2697-Ab-2 | Anti-Feline RFLNB monoclonal antibody | Feline |
| GM-Tg-cang-IP2697-Ab-1/ GM-Tg-cang-IP2697-Ab-2 | Anti-Canine RFLNB monoclonal antibody | Canine |
| GM-Tg-bovg-IP2697-Ab-1/ GM-Tg-bovg-IP2697-Ab-2 | Anti-Bovine RFLNB monoclonal antibody | Bovine |
| GM-Tg-equg-IP2697-Ab-1/ GM-Tg-equg-IP2697-Ab-2 | Anti-Equine RFLNB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2697-Ab-1/ GM-Tg-hg-IP2697-Ab-2; GM-Tg-rg-IP2697-Ab-1/ GM-Tg-rg-IP2697-Ab-2; GM-Tg-mg-IP2697-Ab-1/ GM-Tg-mg-IP2697-Ab-2; GM-Tg-cynog-IP2697-Ab-1/ GM-Tg-cynog-IP2697-Ab-2; GM-Tg-felg-IP2697-Ab-1/ GM-Tg-felg-IP2697-Ab-2; GM-Tg-cang-IP2697-Ab-1/ GM-Tg-cang-IP2697-Ab-2; GM-Tg-bovg-IP2697-Ab-1/ GM-Tg-bovg-IP2697-Ab-2; GM-Tg-equg-IP2697-Ab-1/ GM-Tg-equg-IP2697-Ab-2 |
| Products Name | Anti-RFLNB monoclonal antibody |
| Format | mab |
| Target Name | RFLNB |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RFLNB monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2697-Ag-1 | Recombinant multi-species RFLB/ RFLNB/ CFM1 protein |
| ORF Viral Vector | vGMLP003454 | human RFLNB Lentivirus particle |
| ORF Viral Vector | pGMLP003454 | human RFLNB Lentivirus plasmid |
Target information
| Target ID | GM-IP2697 |
| Target Name | RFLNB |
| Gene ID | 359845,76566,287534,699332,611214,101087112,112442617,100072318 |
| Gene Symbol and Synonyms | 1500005K14Rik,cfm,CFM1,FAM101B,RefilinB,RFLNB,RGD1359691 |
| Uniprot Accession | Q8N5W9,Q6AXS9 |
| Uniprot Entry Name | RFLB_HUMAN,RFLB_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000183688 |
| Target Classification | N/A |
The target: RFLNB, gene name: RFLNB, also named as CFM1, FAM101B. Enables filamin binding activity. Predicted to be involved in several processes, including actin filament bundle organization; negative regulation of bone mineralization involved in bone maturation; and negative regulation of chondrocyte development. Predicted to act upstream of or within actin cytoskeleton organization and epithelial to mesenchymal transition. Predicted to be located in actin cytoskeleton. Predicted to be active in actin filament bundle. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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