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Anti-HBG2 monoclonal antibody
Pre-made anti-HBG2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HBG2/HBG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2887-Ab-1/ GM-Tg-hg-IP2887-Ab-2 | Anti-Human HBG2 monoclonal antibody | Human |
| GM-Tg-rg-IP2887-Ab-1/ GM-Tg-rg-IP2887-Ab-2 | Anti-Rat HBG2 monoclonal antibody | Rat |
| GM-Tg-mg-IP2887-Ab-1/ GM-Tg-mg-IP2887-Ab-2 | Anti-Mouse HBG2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2887-Ab-1/ GM-Tg-cynog-IP2887-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HBG2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2887-Ab-1/ GM-Tg-felg-IP2887-Ab-2 | Anti-Feline HBG2 monoclonal antibody | Feline |
| GM-Tg-cang-IP2887-Ab-1/ GM-Tg-cang-IP2887-Ab-2 | Anti-Canine HBG2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2887-Ab-1/ GM-Tg-bovg-IP2887-Ab-2 | Anti-Bovine HBG2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2887-Ab-1/ GM-Tg-equg-IP2887-Ab-2 | Anti-Equine HBG2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2887-Ab-1/ GM-Tg-hg-IP2887-Ab-2; GM-Tg-rg-IP2887-Ab-1/ GM-Tg-rg-IP2887-Ab-2; GM-Tg-mg-IP2887-Ab-1/ GM-Tg-mg-IP2887-Ab-2; GM-Tg-cynog-IP2887-Ab-1/ GM-Tg-cynog-IP2887-Ab-2; GM-Tg-felg-IP2887-Ab-1/ GM-Tg-felg-IP2887-Ab-2; GM-Tg-cang-IP2887-Ab-1/ GM-Tg-cang-IP2887-Ab-2; GM-Tg-bovg-IP2887-Ab-1/ GM-Tg-bovg-IP2887-Ab-2; GM-Tg-equg-IP2887-Ab-1/ GM-Tg-equg-IP2887-Ab-2 |
| Products Name | Anti-HBG2 monoclonal antibody |
| Format | mab |
| Target Name | HBG2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HBG2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2887-Ag-1 | Recombinant multi-species HBG2/ HBG-T1/ TNCY protein |
| ORF Viral Vector | pGMLP000958 | human HBG2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000958 | human HBG2 Lentivirus particle |
Target information
| Target ID | GM-IP2887 |
| Target Name | HBG2 |
| Gene ID | 3048,114672349 |
| Gene Symbol and Synonyms | HBG-T1,HBG2,TNCY |
| Uniprot Accession | P69892 |
| Uniprot Entry Name | HBG2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | maternal health, Reduced oxygen carrying capacity |
| Gene Ensembl | ENSG00000196565 |
| Target Classification | N/A |
The target: HBG2, gene name: HBG2, also named as HBG-T1, TNCY. The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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