Anti-CAV3/ LGMD1C/ LQT9 monoclonal antibody

Anti-CAV3/ LGMD1C/ LQT9 antibody for FACS & in-vivo assay

Target products collectionGo to CAV3/CAV3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0187-Ab-1/ GM-Tg-hg-MP0187-Ab-2Anti-Human CAV3 monoclonal antibodyHuman
GM-Tg-rg-MP0187-Ab-1/ GM-Tg-rg-MP0187-Ab-2Anti-Rat CAV3 monoclonal antibodyRat
GM-Tg-mg-MP0187-Ab-1/ GM-Tg-mg-MP0187-Ab-2Anti-Mouse CAV3 monoclonal antibodyMouse
GM-Tg-cynog-MP0187-Ab-1/ GM-Tg-cynog-MP0187-Ab-2Anti-Cynomolgus/ Rhesus macaque CAV3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0187-Ab-1/ GM-Tg-felg-MP0187-Ab-2Anti-Feline CAV3 monoclonal antibodyFeline
GM-Tg-cang-MP0187-Ab-1/ GM-Tg-cang-MP0187-Ab-2Anti-Canine CAV3 monoclonal antibodyCanine
GM-Tg-bovg-MP0187-Ab-1/ GM-Tg-bovg-MP0187-Ab-2Anti-Bovine CAV3 monoclonal antibodyBovine
GM-Tg-equg-MP0187-Ab-1/ GM-Tg-equg-MP0187-Ab-2Anti-Equine CAV3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0187-Ab-1/ GM-Tg-hg-MP0187-Ab-2; GM-Tg-rg-MP0187-Ab-1/ GM-Tg-rg-MP0187-Ab-2;
GM-Tg-mg-MP0187-Ab-1/ GM-Tg-mg-MP0187-Ab-2; GM-Tg-cynog-MP0187-Ab-1/ GM-Tg-cynog-MP0187-Ab-2;
GM-Tg-felg-MP0187-Ab-1/ GM-Tg-felg-MP0187-Ab-2; GM-Tg-cang-MP0187-Ab-1/ GM-Tg-cang-MP0187-Ab-2;
GM-Tg-bovg-MP0187-Ab-1/ GM-Tg-bovg-MP0187-Ab-2; GM-Tg-equg-MP0187-Ab-1/ GM-Tg-equg-MP0187-Ab-2
Products NameAnti-CAV3 monoclonal antibody
Formatmab
Target NameCAV3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CAV3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CAV3/ LGMD1C/ LQT9 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP002892human CAV3 Lentivirus plasmid
    ORF Viral VectorvGMLP002892human CAV3 Lentivirus particle
    ORF Viral VectorpGMAD000634Norway rat Cav3 Adenovirus plasmid
    ORF Viral VectorpGMAAV000277Norway rat Cav3 AAV plasmid
    ORF Viral VectorpGMAAV000361house mouse Cav3 AAV plasmid
    ORF Viral VectorpGMLPm001557mouse Cav3 Lentivirus plasmid
    ORF Viral VectorvGMAD000634Norway rat Cav3 Adenovirus particle
    ORF Viral VectorvGMAAV000277Norway rat Cav3 AAV particle
    ORF Viral VectorvGMAAV000361house mouse Cav3 AAV particle
    ORF Viral VectorvGMLPm001557mouse Cav3 Lentivirus particle


    Target information

    Target IDGM-MP0187
    Target NameCAV3
    Gene ID859,12391,29161,702163,484671,101081453,615310,100058881
    Gene Symbol and SynonymsCav-3,CAV3,LGMD1C,LQT9,M-cav,MPDT,RMD2,VIP-21,VIP21
    Uniprot AccessionP56539,P51638,Q2KI43
    Uniprot Entry NameCAV3_HUMAN,CAV3_RAT,CAV3_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000182533
    Target ClassificationN/A

    The target: CAV3, gene name: CAV3, also named as LGMD1C, LQT9, MPDT, RMD2, VIP-21, VIP21. This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.