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Anti-CFC1/ CFC1B/ CRYPTIC monoclonal antibody
Anti-CFC1/ CFC1B/ CRYPTIC antibody for FACS & in-vivo assay
Go to CFC1/CFC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0255-Ab-1/ GM-Tg-hg-MP0255-Ab-2 | Anti-Human CFC1 monoclonal antibody | Human |
| GM-Tg-rg-MP0255-Ab-1/ GM-Tg-rg-MP0255-Ab-2 | Anti-Rat CFC1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0255-Ab-1/ GM-Tg-mg-MP0255-Ab-2 | Anti-Mouse CFC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0255-Ab-1/ GM-Tg-cynog-MP0255-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CFC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0255-Ab-1/ GM-Tg-felg-MP0255-Ab-2 | Anti-Feline CFC1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0255-Ab-1/ GM-Tg-cang-MP0255-Ab-2 | Anti-Canine CFC1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0255-Ab-1/ GM-Tg-bovg-MP0255-Ab-2 | Anti-Bovine CFC1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0255-Ab-1/ GM-Tg-equg-MP0255-Ab-2 | Anti-Equine CFC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0255-Ab-1/ GM-Tg-hg-MP0255-Ab-2; GM-Tg-rg-MP0255-Ab-1/ GM-Tg-rg-MP0255-Ab-2; GM-Tg-mg-MP0255-Ab-1/ GM-Tg-mg-MP0255-Ab-2; GM-Tg-cynog-MP0255-Ab-1/ GM-Tg-cynog-MP0255-Ab-2; GM-Tg-felg-MP0255-Ab-1/ GM-Tg-felg-MP0255-Ab-2; GM-Tg-cang-MP0255-Ab-1/ GM-Tg-cang-MP0255-Ab-2; GM-Tg-bovg-MP0255-Ab-1/ GM-Tg-bovg-MP0255-Ab-2; GM-Tg-equg-MP0255-Ab-1/ GM-Tg-equg-MP0255-Ab-2 |
| Products Name | Anti-CFC1 monoclonal antibody |
| Format | mab |
| Target Name | CFC1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CFC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CFC1/ CFC1B/ CRYPTIC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000732 | human CFC1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000732 | human CFC1 Lentivirus particle |
| ORF Viral Vector | pGMLPm004532 | mouse Cfc1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004532 | mouse Cfc1 Lentivirus particle |
Target information
| Target ID | GM-MP0255 |
| Target Name | CFC1 |
| Gene ID | 55997 |
| Gene Symbol and Synonyms | CFC1,CFC1B,CRYPTIC,DTGA2,HTX2 |
| Uniprot Accession | P0CG37 |
| Uniprot Entry Name | CFC1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136698 |
| Target Classification | N/A |
The target: CFC1, gene name: CFC1, also named as CFC1B, CRYPTIC, DTGA2, HTX2. This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
