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Anti-ACHB3/ CHRNB3 monoclonal antibody
Anti-ACHB3/ CHRNB3 antibody for FACS & in-vivo assay
Go to CHRNB3/CHRNB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0262-Ab-1/ GM-Tg-hg-MP0262-Ab-2 | Anti-Human CHRNB3 monoclonal antibody | Human |
| GM-Tg-rg-MP0262-Ab-1/ GM-Tg-rg-MP0262-Ab-2 | Anti-Rat CHRNB3 monoclonal antibody | Rat |
| GM-Tg-mg-MP0262-Ab-1/ GM-Tg-mg-MP0262-Ab-2 | Anti-Mouse CHRNB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0262-Ab-1/ GM-Tg-cynog-MP0262-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRNB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0262-Ab-1/ GM-Tg-felg-MP0262-Ab-2 | Anti-Feline CHRNB3 monoclonal antibody | Feline |
| GM-Tg-cang-MP0262-Ab-1/ GM-Tg-cang-MP0262-Ab-2 | Anti-Canine CHRNB3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0262-Ab-1/ GM-Tg-bovg-MP0262-Ab-2 | Anti-Bovine CHRNB3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0262-Ab-1/ GM-Tg-equg-MP0262-Ab-2 | Anti-Equine CHRNB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0262-Ab-1/ GM-Tg-hg-MP0262-Ab-2; GM-Tg-rg-MP0262-Ab-1/ GM-Tg-rg-MP0262-Ab-2; GM-Tg-mg-MP0262-Ab-1/ GM-Tg-mg-MP0262-Ab-2; GM-Tg-cynog-MP0262-Ab-1/ GM-Tg-cynog-MP0262-Ab-2; GM-Tg-felg-MP0262-Ab-1/ GM-Tg-felg-MP0262-Ab-2; GM-Tg-cang-MP0262-Ab-1/ GM-Tg-cang-MP0262-Ab-2; GM-Tg-bovg-MP0262-Ab-1/ GM-Tg-bovg-MP0262-Ab-2; GM-Tg-equg-MP0262-Ab-1/ GM-Tg-equg-MP0262-Ab-2 |
| Products Name | Anti-CHRNB3 monoclonal antibody |
| Format | mab |
| Target Name | CHRNB3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRNB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACHB3/ CHRNB3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003723 | human CHRNB3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003723 | human CHRNB3 Lentivirus particle |
| ORF Viral Vector | pGMLPm002949 | mouse Chrnb3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002949 | mouse Chrnb3 Lentivirus particle |
Target information
| Target ID | GM-MP0262 |
| Target Name | CHRNB3 |
| Gene ID | 1142,108043,171131,720301,482837,101098624,521702,100054095 |
| Gene Symbol and Synonyms | 5730417K16Rik,Acrb3,CHRNB3,nicb3 |
| Uniprot Accession | Q05901,P12391 |
| Uniprot Entry Name | ACHB3_HUMAN,ACHB3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000147432 |
| Target Classification | N/A |
The target: CHRNB3, gene name: CHRNB3, also named as . The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997.
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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