- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-ACHE/ CHRNE/ ACHRE monoclonal antibody
Anti-ACHE/ CHRNE/ ACHRE antibody for FACS & in-vivo assay
Go to CHRNE/CHRNE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0264-Ab-1/ GM-Tg-hg-MP0264-Ab-2 | Anti-Human CHRNE monoclonal antibody | Human |
| GM-Tg-rg-MP0264-Ab-1/ GM-Tg-rg-MP0264-Ab-2 | Anti-Rat CHRNE monoclonal antibody | Rat |
| GM-Tg-mg-MP0264-Ab-1/ GM-Tg-mg-MP0264-Ab-2 | Anti-Mouse CHRNE monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0264-Ab-1/ GM-Tg-cynog-MP0264-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRNE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0264-Ab-1/ GM-Tg-felg-MP0264-Ab-2 | Anti-Feline CHRNE monoclonal antibody | Feline |
| GM-Tg-cang-MP0264-Ab-1/ GM-Tg-cang-MP0264-Ab-2 | Anti-Canine CHRNE monoclonal antibody | Canine |
| GM-Tg-bovg-MP0264-Ab-1/ GM-Tg-bovg-MP0264-Ab-2 | Anti-Bovine CHRNE monoclonal antibody | Bovine |
| GM-Tg-equg-MP0264-Ab-1/ GM-Tg-equg-MP0264-Ab-2 | Anti-Equine CHRNE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0264-Ab-1/ GM-Tg-hg-MP0264-Ab-2; GM-Tg-rg-MP0264-Ab-1/ GM-Tg-rg-MP0264-Ab-2; GM-Tg-mg-MP0264-Ab-1/ GM-Tg-mg-MP0264-Ab-2; GM-Tg-cynog-MP0264-Ab-1/ GM-Tg-cynog-MP0264-Ab-2; GM-Tg-felg-MP0264-Ab-1/ GM-Tg-felg-MP0264-Ab-2; GM-Tg-cang-MP0264-Ab-1/ GM-Tg-cang-MP0264-Ab-2; GM-Tg-bovg-MP0264-Ab-1/ GM-Tg-bovg-MP0264-Ab-2; GM-Tg-equg-MP0264-Ab-1/ GM-Tg-equg-MP0264-Ab-2 |
| Products Name | Anti-CHRNE monoclonal antibody |
| Format | mab |
| Target Name | CHRNE |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRNE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACHE/ CHRNE/ ACHRE VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0264 |
| Target Name | CHRNE |
| Gene ID | 1145,11448,29422,710301,479471,101092560,281688,100146223 |
| Gene Symbol and Synonyms | ACHRE,AChrepsilon,Acre,CHRNE,CMS1A1,CMS1D,CMS1E,CMS2A,CMS4A,CMS4B,CMS4C,FCCMS,FIM1,FIMG,FIMG1,MGI,nAChR,nAChRE,SCCMS |
| Uniprot Accession | Q04844,P09660,P02715 |
| Uniprot Entry Name | ACHE_HUMAN,ACHE_RAT,ACHE_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000108556 |
| Target Classification | N/A |
The target: CHRNE, gene name: CHRNE, also named as ACHRE, CMS1D, CMS1E, CMS2A, CMS4A, CMS4B, CMS4C, FCCMS, SCCMS. Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
