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Anti-ACHG/ CHRNG/ ACHRG monoclonal antibody
Anti-ACHG/ CHRNG/ ACHRG antibody for FACS & in-vivo assay
Go to CHRNG/CHRNG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0265-Ab-1/ GM-Tg-hg-MP0265-Ab-2 | Anti-Human CHRNG monoclonal antibody | Human |
| GM-Tg-rg-MP0265-Ab-1/ GM-Tg-rg-MP0265-Ab-2 | Anti-Rat CHRNG monoclonal antibody | Rat |
| GM-Tg-mg-MP0265-Ab-1/ GM-Tg-mg-MP0265-Ab-2 | Anti-Mouse CHRNG monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0265-Ab-1/ GM-Tg-cynog-MP0265-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRNG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0265-Ab-1/ GM-Tg-felg-MP0265-Ab-2 | Anti-Feline CHRNG monoclonal antibody | Feline |
| GM-Tg-cang-MP0265-Ab-1/ GM-Tg-cang-MP0265-Ab-2 | Anti-Canine CHRNG monoclonal antibody | Canine |
| GM-Tg-bovg-MP0265-Ab-1/ GM-Tg-bovg-MP0265-Ab-2 | Anti-Bovine CHRNG monoclonal antibody | Bovine |
| GM-Tg-equg-MP0265-Ab-1/ GM-Tg-equg-MP0265-Ab-2 | Anti-Equine CHRNG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0265-Ab-1/ GM-Tg-hg-MP0265-Ab-2; GM-Tg-rg-MP0265-Ab-1/ GM-Tg-rg-MP0265-Ab-2; GM-Tg-mg-MP0265-Ab-1/ GM-Tg-mg-MP0265-Ab-2; GM-Tg-cynog-MP0265-Ab-1/ GM-Tg-cynog-MP0265-Ab-2; GM-Tg-felg-MP0265-Ab-1/ GM-Tg-felg-MP0265-Ab-2; GM-Tg-cang-MP0265-Ab-1/ GM-Tg-cang-MP0265-Ab-2; GM-Tg-bovg-MP0265-Ab-1/ GM-Tg-bovg-MP0265-Ab-2; GM-Tg-equg-MP0265-Ab-1/ GM-Tg-equg-MP0265-Ab-2 |
| Products Name | Anti-CHRNG monoclonal antibody |
| Format | mab |
| Target Name | CHRNG |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRNG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACHG/ CHRNG/ ACHRG VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0265 |
| Target Name | CHRNG |
| Gene ID | 1146,11449,25753,713418,486163,101098733,281689,100057215 |
| Gene Symbol and Synonyms | Achr-3,ACHRG,Acrg,CHRNG |
| Uniprot Accession | P07510,P18916,P13536 |
| Uniprot Entry Name | ACHG_HUMAN,ACHG_RAT,ACHG_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000196811 |
| Target Classification | N/A |
The target: CHRNG, gene name: CHRNG, also named as ACHRG. The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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