Anti-CLCA2/ CACC/ CACC3 monoclonal antibody

Anti-CLCA2/ CACC/ CACC3 antibody for FACS & in-vivo assay

Target products collectionGo to CLCA2/CLCA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0267-Ab-1/ GM-Tg-hg-MP0267-Ab-2Anti-Human CLCA2 monoclonal antibodyHuman
GM-Tg-rg-MP0267-Ab-1/ GM-Tg-rg-MP0267-Ab-2Anti-Rat CLCA2 monoclonal antibodyRat
GM-Tg-mg-MP0267-Ab-1/ GM-Tg-mg-MP0267-Ab-2Anti-Mouse CLCA2 monoclonal antibodyMouse
GM-Tg-cynog-MP0267-Ab-1/ GM-Tg-cynog-MP0267-Ab-2Anti-Cynomolgus/ Rhesus macaque CLCA2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0267-Ab-1/ GM-Tg-felg-MP0267-Ab-2Anti-Feline CLCA2 monoclonal antibodyFeline
GM-Tg-cang-MP0267-Ab-1/ GM-Tg-cang-MP0267-Ab-2Anti-Canine CLCA2 monoclonal antibodyCanine
GM-Tg-bovg-MP0267-Ab-1/ GM-Tg-bovg-MP0267-Ab-2Anti-Bovine CLCA2 monoclonal antibodyBovine
GM-Tg-equg-MP0267-Ab-1/ GM-Tg-equg-MP0267-Ab-2Anti-Equine CLCA2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0267-Ab-1/ GM-Tg-hg-MP0267-Ab-2; GM-Tg-rg-MP0267-Ab-1/ GM-Tg-rg-MP0267-Ab-2;
GM-Tg-mg-MP0267-Ab-1/ GM-Tg-mg-MP0267-Ab-2; GM-Tg-cynog-MP0267-Ab-1/ GM-Tg-cynog-MP0267-Ab-2;
GM-Tg-felg-MP0267-Ab-1/ GM-Tg-felg-MP0267-Ab-2; GM-Tg-cang-MP0267-Ab-1/ GM-Tg-cang-MP0267-Ab-2;
GM-Tg-bovg-MP0267-Ab-1/ GM-Tg-bovg-MP0267-Ab-2; GM-Tg-equg-MP0267-Ab-1/ GM-Tg-equg-MP0267-Ab-2
Products NameAnti-CLCA2 monoclonal antibody
Formatmab
Target NameCLCA2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CLCA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CLCA2/ CACC/ CACC3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0267
    Target NameCLCA2
    Gene ID9635,229933,308016,711959,612510,101100988,534256,100052615
    Gene Symbol and Synonyms4732440A06,CACC,CaCC-3,CACC3,CLCA2,Clca5,CLCRG2
    Uniprot AccessionQ9UQC9
    Uniprot Entry NameCLCA2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000137975
    Target ClassificationN/A

    The target: CLCA2, gene name: CLCA2, also named as CACC, CACC3, CLCRG2, CaCC-3. This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.