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Anti-CLCN5/ CLC5/ CLCK2 monoclonal antibody
Anti-CLCN5/ CLC5/ CLCK2 antibody for FACS & in-vivo assay
Go to CLCN5/CLCN5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0269-Ab-1/ GM-Tg-hg-MP0269-Ab-2 | Anti-Human CLCN5 monoclonal antibody | Human |
| GM-Tg-rg-MP0269-Ab-1/ GM-Tg-rg-MP0269-Ab-2 | Anti-Rat CLCN5 monoclonal antibody | Rat |
| GM-Tg-mg-MP0269-Ab-1/ GM-Tg-mg-MP0269-Ab-2 | Anti-Mouse CLCN5 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0269-Ab-1/ GM-Tg-cynog-MP0269-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLCN5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0269-Ab-1/ GM-Tg-felg-MP0269-Ab-2 | Anti-Feline CLCN5 monoclonal antibody | Feline |
| GM-Tg-cang-MP0269-Ab-1/ GM-Tg-cang-MP0269-Ab-2 | Anti-Canine CLCN5 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0269-Ab-1/ GM-Tg-bovg-MP0269-Ab-2 | Anti-Bovine CLCN5 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0269-Ab-1/ GM-Tg-equg-MP0269-Ab-2 | Anti-Equine CLCN5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0269-Ab-1/ GM-Tg-hg-MP0269-Ab-2; GM-Tg-rg-MP0269-Ab-1/ GM-Tg-rg-MP0269-Ab-2; GM-Tg-mg-MP0269-Ab-1/ GM-Tg-mg-MP0269-Ab-2; GM-Tg-cynog-MP0269-Ab-1/ GM-Tg-cynog-MP0269-Ab-2; GM-Tg-felg-MP0269-Ab-1/ GM-Tg-felg-MP0269-Ab-2; GM-Tg-cang-MP0269-Ab-1/ GM-Tg-cang-MP0269-Ab-2; GM-Tg-bovg-MP0269-Ab-1/ GM-Tg-bovg-MP0269-Ab-2; GM-Tg-equg-MP0269-Ab-1/ GM-Tg-equg-MP0269-Ab-2 |
| Products Name | Anti-CLCN5 monoclonal antibody |
| Format | mab |
| Target Name | CLCN5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLCN5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CLCN5/ CLC5/ CLCK2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0269 |
| Target Name | CLCN5 |
| Gene ID | 1184,12728,25749,694497,491882,101085351,493644,100052289 |
| Gene Symbol and Synonyms | 5430408K11Rik,ClC-5,Clc4-1,CLC5,CLCK2,CLCN3,Clcn4-1,CLCN5,D930009B12Rik,DENT1,DENTS,DXImx42e,hCIC-K2,NPHL1,NPHL2,Sfc13,XLRH,XRN |
| Uniprot Accession | P51795,P51796 |
| Uniprot Entry Name | CLCN5_HUMAN,CLCN5_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000171365 |
| Target Classification | N/A |
The target: CLCN5, gene name: CLCN5, also named as CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2. This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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